San Francisco Giants vs Milwaukee Brewers Prediction, Odds and Picks for Today, 06/01/26

The San Francisco Giants and Milwaukee Brewers will be opening up a four-game series in Milwaukee on Monday night. The Brewers have one of the best records in all of baseball right now, and they are very dominant at home with a 19-11 record at American Family Field. It appears to be a bull-pen day for the Brewers, which is alright because they give up the fourth-fewest runs per game as a team in the MLB. They average 3.5 runs allowed per game. Heading into action on Sunday where the Giants scored 19 runs at Coors Field, the Giants were the worst offensive team in the league, averaging 3.7 runs per game. This won’t be enough to keep pace with a solid defensive team in the Brewers, and a Brewers team that averages 4.8 runs per game, sixth-best in the league.

Landon Roupp will have to be good for the Giants to give them a chance in this game. The Giants are only 3-7 in their last 10, and I think they are out-classed in this matchup. I am going to side with the Brewers in this one on the money line.

Giants vs. Brewers prediction: Brewers ML (-140) available at time of publishing. Playable to -150.