Washington Nationals vs Chicago White Sox Prediction, Odds and Picks for Today, 04/25/26

The Washington Nationals will take on the Chicago White Sox Saturday. In the first game of the series, the White Sox won 5-4. On the mound in this one will be Jake Irvin of the Nationals and Noah Schultz of the White Sox. Irvin has struggled this season with a 1-3 record and a 6.00 ERA. Through his last 4 starts, he has pitched 19.0 innings while giving up 17 hits, 10 walks and 14 earned runs. The issues for Irvin have been walks and home runs this season. It may be a short day for him as he goes up against a White Sox team that has won 4 of their last 5 games while scoring 34 runs in that time.

For the White Sox, Schultz will take the mound. He is coming off a great start where he pitched 5.0 innings while giving up just 1 hit and 1 run against the Athletics. He will go up against a Nationals team that is batting .250 this season with 12 runs in their last 3 games. The hitting for the Nationals has not been the issue. The Nationals struggle to stop opposing teams from scoring. Through their last 3 games, they have given up 20 runs. I expect the White Sox to score plenty today and come away victorious.

Nationals vs White Sox prediction: Chicago ML (-140) available at time of publishing. Playable at that number.

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