MLB Saturday mega parlay (+965 odds): Webb, Burnes and Lopez to dominate

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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email

After an eventful week across the MLB, we have another packed slate on Saturday with a number of great matchups. And what better way to celebrate a great day of baseball than by going for a big payday? That’s right; we’re back with another mega parlay with a payout of just under 10/1 at DraftKings Sportsbook.

Before we dive in, don’t forget to check out our free picks on the side and total for every MLB game today. Let’s get into our mega parlay for Saturday.

San Francisco Giants -1.5 (+165)

Milwaukee Brewers ML (-115)

Miami Marlins ML (+115)

Parlay odds: +965

Let’s break down each of the legs one by one.

Odds available at DraftKings Sportsbook at time of publishing. 

San Francisco Giants -1.5 (+165) over St. Louis Cardinals

To start this mega parlay we have the Giants on the run line. While San Francisco is in the midst of a 5-game skid, the Giants are still playing at home with the much better starting pitcher. Logan Webb is still one of the better pitchers in the NL and has already posted five quality starts this season. He’ll be opposed by Steven Matz, who has been rather inconsistent through the first month of the campaign. The lefty has allowed 12 runs on the season, with 7 of those coming in his 2022 debut. Matz’s best outings have come against the Reds, Pirates and Royals. This presents a significant step up in class on the road.

The Giants should come out desperate to stop their skid, and I think their offense finally wakes up at home. If the bats can provide Webb with an early cushion, San Francisco should get back in the win column.

Check out our full Cardinals vs Giants game preview

Milwaukee Brewers ML (-115) over Atlanta Braves

The second leg of this parlay has us backing the Milwaukee Brewers on the money line. After a slow start to 2022, the Brew Crew have found their footing and lead the NL Central. Unsurprisingly, Milwaukee has been lead by its pitching. Look no further than Corbin Burnes, who has picked up right where he left off a season ago. In his first 5 starts, the Cy Young winner has struck out 43 hitters and holds a 1.93 ERA. Burnes should continue to hold serve against a Braves team that is having trouble getting off the ground. And while Max Fried has found his groove in recent starts, expect a tougher challenge for the Braves’ left-hander against a surprisingly solid Milwaukee lineup.

Atlanta’s talent is undeniable, but the defending champions are not quite clicking just yet. On the other side, Burnes is at the top of his game and the Brewers offense is absolutely rolling. Look for Milwaukee to come out on top in this battle of the aces on Saturday.

Miami Marlins ML (+115) over San Diego Padres

To take us home, we have the Miami Marlins on the money line. The Marlins are just 12-14, but this team feels much better than its record suggests. Miami quietly has a very good rotation that has put up rock solid numbers through the first 26 games. The problem is the Fish can’t hit in big spots, as the Marlins have lost 5 straight games by 1 run, including the first 2 games of this series against the Padres. Miami has shown they can hang with San Diego, and that won’t change with Pablo Lopez getting the start on Saturday.

Lopez has allowed just 5 runs in 28 innings, with 4 of those coming in his most recent start. Against a Padres lineup ranked 12th in the National League, the right-hander should give the Marlins a good chance to win once again. Lopez will be opposed by Sean Manaea, who has surrendered 9 runs in his last 10 IP. Manaea should be better at home, but this game presents a great chance for Miami’s offense to break through.

The first couple of games in this series were pitchers duels decided by 1 run. At some point, the Marlins have to get over the hump and win one of these close contests. At plus money, let’s hope the Fish can finally secure a victory.

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