MLB Wednesday parlay at mega +826 odds today 6/5: Cubs dominate at home

Chicago Cubs center fielder Cody Bellinger (24) is greeted by second baseman Nico Hoerner (2) after hitting a two-run home run against the Kansas City Royals during the first inning at Wrigley Field.
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Caleb Wilfinger


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Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email
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The MLB season rolls on today with a full slate of games on the docket on Wednesday as a number of teams play during the day, while we’ll see about a half dozen primetime games to close out the day. With the entirety of the league in action on Wednesday, there is plenty to attack and craft an MLB mega parlay. Let’s dive into today’s MLB parlay picks, with games getting underway with the Braves taking on the Red Sox at 1:35 pm ET and concluding with the Mariners taking on the A’s at 9:35 pm ET. You can also check out all of our MLB picks for today’s action.

Cubs -1.5 (+110)

Padres -1.5 (+110)

Mariners -1.5 (+110)

MLB parlay odds: +826

For this MLB parlay, I am going with a bet on the Cubs, Padres and Mariners to win by multiple runs. Let’s break down each of the 3 legs.

Chicago Cubs -1.5 over Chicago White Sox (+110)

To start off our MLB parlay, I’m going with the Chicago Cubs on the run line on Wednesday. Fading the White Sox is rarely a bad option and the Cubs have the edge on the mound and at the plate in this matchup. White Sox starter Erick Fedde is 4-0 with a 0.95 ERA in 6 home starts, but he is 0-1 with a 5.74 ERA in 6 road starts. Additionally, the White Sox are just 1-5 in his 6 road starts, losing games to the Brewers, Blue Jays, Cardinals, Twins, Guardians and Royals. For the hosts, Jameson Taillon will get the start, and he is 3-2 with a 2.84 ERA in 8 starts this season. Furthermore, he is 3-1 with a 2.11 ERA in 4 starts at Wrigley Field this year, with wins over the Marlins, Astros, Brewers and Pirates. All signs point to a Cubs win so let’s grab the value on the run line.

Read our full Chicago White Sox vs Chicago Cubs predictions

San Diego Padres -1.5 over Los Angeles Angels (+110) 

For the second leg in our MLB parlay, I’m going with the Padres on the run line. San Diego is looking to avoid a sweep at the hands of a struggling Angels team, and they’ll turn to Dylan Cease (3.42 ERA, 0.97 WHIP) to do so. Cease’s strikeout rate is one of the best in MLB (11.03 K/9) and his 3.22 xERA suggests that he should put forth another strong start on Wednesday. It helps that he’ll face an Angels lineup that struggles against righties, as Los Angeles ranks 23rd in BA (.226) and 26th in wRC+ (86) against right-handed pitching. Furthermore, Angels starter Jose Soriano has a decent 3.98 xERA, but struggles with walks (3.86 BB/9) and has been worse off at home with a 6.75 ERA and .250 OBA when playing in Anaheim. He’s surrendered 4 earned runs in 3 consecutive starts and has one of the worst bullpens in baseball backing him up in relief, so let’s go with the Padres to win comfortably.

Read our full San Diego Padres vs Los Angeles Angels predictions

Seattle Mariners -1.5 over Oakland Athletics (+110) 

To close out this MLB parlay, I have the Seattle Mariners on the run line. The Mariners’ offense has been a frustrating endeavor to watch this season, but one thing that Seattle does extremely well is pitch and it holds a significant advantage in that department in this contest. We’re getting an advantageous matchup for Seattle starter Logan Gilbert, as Oakland boasts the league’s 3rd-highest K% at 26.6% over the last 30 days. Outside of an outlier start against the Twins where he allowed 8 runs in 4 innings pitched, Gilbert has been rock solid this season and I don’t expect the A’s offense to pose much of a threat to that trend of success. Conversely, Joey Estes (6.10 ERA) getting the ball means that Seattle should scratch across at least a handful of runs in this one. Let’s take the Mariners on the run line.

You can also check out today’s best MLB player prop bets, with our experts on an 8-1 run!

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