NFL betting guide: Expert Week 1 NFL predictions, picks, odds & best bets
Welcome to the Pickswise NFL Week 1 betting guide! We have arrived at the beginning of the regular season, which kicked off on Thursday night with a big win for the defending Super Bowl champion Kansas City Chiefs over the visiting Baltimore Ravens.
Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend. You can also read our great NFL predictions for every game on the opening slate of the NFL regular season.
NFL Week 1 picks
- NFL picks against the spread and total for EVERY Week 1 game
- NFL best bets
- NFL parlays
NFL Week 1 expert betting picks and predictions
- Pickswise experts’ best bets
- NFL Week 1 mega parlay (+1428 odds!)
- Dallas Cowboys vs Cleveland Browns Same Game Parlay
- Los Angeles Rams vs Detroit Lions SNF Same Game Parlay
NFL Week 1 prop bets
- Week 1 touchdown scorer best bets
- Sunday player prop best bets
- Sunday Night Football prop bets – from Prop Holliday
- Sunday Night Football touchdown scorer bets
NFL Week 1 big-game predictions
- Texans vs Colts predictions
- Jaguars vs Dolphins predictions
- Steelers vs Falcons predictions
- Cowboys vs Browns predictions
- Rams vs Lions predictions
- Jets vs 49ers predictions
