NFL betting guide: Expert 2022 Week 17 NFL picks, predictions, odds & best bets

Buffalo Bills running back Devin Singletary (26) celebrates his touchdown against the Miami Dolphins during the first half at Hard Rock Stadium.
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Phil Agius


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I've been writing about the NFL and a host of other sports for the UK's top daily betting paper the Racing Post for more than 20 years. An incurable Browns fan (1-31 survivor), I also specialise in all kinds of motorsport betting including F1, MotoGP, IndyCar and NASCAR. For Phil Agius media enquiries, please email

Welcome to the Pickswise NFL Week 17 betting guide! Significantly fewer teams will still be listed in the ‘In The Hunt’ graphics after the penultimate slate of games has been played, but which teams will be able to take their challenges down to the final week and which could achieve their aims without needing a Week 18 win?

We’ve already seen in the first game of Week 17 that playoff positioning and motivations are going to matter a lot this week — the Titans took no risks with their season depending on next week’s winner-take-all game against the Jaguars and lost 27-13 to the Cowboys.

There are 9 games on Sunday’s 1:00pm slate with Dolphins vs Patriots and Panthers vs Buccaneers among the more interesting games, while the late afternoon slate includes Jets vs Seahawks and Vikings vs Packers before the AFC North clash between the Steelers and Ravens on Sunday Night Football at 8:20pm ET.

Our experts have done the hard work so you have everything you need to bet better and get the right results. This is your one-stop shop for everything you need to make the most of your NFL weekend — and Monday night’s big AFC showdown between the Bills and Bengals which could be a key game in determining the playoff seedings.

It’s also the first NFL slate that bettors in Ohio will be able to wager on legally, so don’t forget to check out the best Ohio promo codes and welcome offers! You can also read our great NFL predictions for every game on the Week 17 slate.

NFL Week 17 picks

  • NFL picks against the spread and total for EVERY Week 17 game – we’re 137-99-5 on sides for +44.7 units of profit this season!
  • NFL best bets – we have a 47-36 record on our 3-star plays this season 
  • NFL parlays

NFL Week 17 expert betting picks and predictions

NFL Week 17 prop bets

NFL Week 17 Promo Codes

Find all the latest Sportsbook Promo Codes and Bonuses for NFL Week 17, including sportsbooks live in your state.

NFL Week 17 big-game predictions

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