Commanders vs 49ers Predictions, Picks, Odds & Betting Guide
We round off NFL Week 6 with an intriguing Monday Night Football matchup in the NFC, as the undefeated San Francisco 49ers host the Washington Commanders. The 49ers are currently the Super Bowl favorites with a number of sportsbooks following their red-hot start (and the disaster developing with the Rams). As for the Commanders, they enter this one at 1-3-1, on the heels of a disastrous end to their matchup against the Giants that finished as a tie.
Commanders vs 49ers kicks off at 8:15 PM ET tonight live on ESPN, and we've got everything you need to bet on this MNF matchup in the NFC. You can find out our expert NFL picks on the side and total for this game, along with every matchup throughout the entire season. Plus, we have JutPicks' anytime touchdown scorer predictions as he looks to add to four winners in the past four weeks at +400, +330, +280 and +300 odds! Plus, after back-to-back winners at +650 and +700, we've got our Commanders vs 49ers Same Game Parlay picks as we look to make it three MNF winners in a row. Let’s break it all down.
Commanders vs 49ers Latest MNF Odds
Odds courtesy of bet365 and available at 10:00 AM ET on Monday, October 19. Find out the latest NFL odds for every Week 7 matchup.
Money Line: Commanders (+350) vs 49ers (-450)
Point Spread: Commanders +7.5 (-111) vs 49ers -7.5 (-109)
Game Totals: Over 51.5 (-113), Under 51.5 (-107)
Commanders vs 49ers Predictions & Picks
Chris Farley’s Commanders vs 49ers Spread Pick: Commanders +7.5 (-111)
The 49ers are 5-0 and look like the best team in the NFL, but the Commanders should be able to at least stay within a touchdown here. Washington is composed of experienced NFL players, and Jayden Daniels adds a dynamic that San Francisco will struggle to slow down. Luck has gone against the Commanders, but with the 49ers banged up, that could change here.
Chris Farley’s Commanders vs 49ers Total Prediction: Over 51.5 (-108)
The 49ers boast the best offense in the NFL, averaging 30.8 points per game while reaching at least 24 points in all five of their wins. The Commanders' defense has allowed the most second-half points in the NFL, which is bad news for them. Meanwhile, Washington QB Jayden Daniels' return should give the Commanders life, and they should play their part in a shootout.
Don't miss pro NFL bettor Chris Farley's Commanders vs 49ers predictions on the side and total for MNF - he's up +16.6 units this season!
Commanders vs 49ers Player Prop Bets
Commanders vs 49ers TD scorer best bet: Jacob Cowing (SF) Anytime Touchdown Scorer (+440)
The 49ers' wide receiver room is a mess at the moment. Mike Evans is listed as questionable, while the likes of Deebo Samuel and Demarcus Robinson are already ruled out. We're looking to find value in the 49ers' WR room to find the end zone, and we're targeting 2024 fourth-round pick Jacob Cowing, who ran 17 routes last week.
After four straight weeks of nailing MNF TD scorers at +400, +330, +280 and +300 odds, find out Justin Martin's Commanders vs 49ers anytime touchdown scorer best bets for tonight, featuring another pick at +410!
Washington Commanders vs San Francisco 49ers Same Game Parlay
49ers -9.5 alternate spread over Commanders (+150)
Just two years ago, it looked like the Commanders were a team on the rise, catapulted by a young quarterback Jayden Daniels – who looked like he could transform the franchise. Fast forward to 2026 and head coach Dan Quinn’s crew is on a steep and alarming decline. Meanwhile, San Francisco ranks in the top three of the NFL in both passing offense and passing defense. In this day and age, that is going to get you places. And it should get the Niners another win on MNF.
George Kittle (SF) to Record 70+ Receiving Yards (+107)
Kittle should be in line for a huge outing at Washington’s expense. The Commanders rank #29 in the league against the pass, conceding 255.0 yards per game on 7.1 yards per pass attempt. They are allowing the second-most fantasy points to tight ends, ahead of only the Lions in that department. Meanwhile, Kittle has produced 70 receiving yards or more in three of his last four games. This stretch features performances of 80 yards against the Dolphins and 82 yards against the Cardinals.
George Kittle (SF) to Score a Touchdown (+110)
Kittle has scored four touchdowns in the last four games. The former Iowa standout loves the big stage and has a history of success in primetime. In his last two standalone night games in the 2025 campaign, Kittle caught six of 10 targets for 78 yards in a Week 12 victory over the Panthers and then caught seven of eight targets for 115 yards and one TD during a Week 16 defeat of Indianapolis. He now faces a Washington defense that is giving up 29.8 points per game.
Commanders vs 49ers SGP odds: +525
We've cashed our last two MNF SGPs at +650 and +700 odds! Don't miss our Commanders vs 49ers Same Game Parlay tonight as we look to make it three in a row
NFL Week 7 Picks
Keep an eye out for our expert NFL predictions for every Week 7 game as they are added throughout the week!
