Giants vs Rams Predictions, Picks, Odds & Betting Guide

NFL Week 2 wraps up with a crunch Monday night Football matchup in the NFC, as the New York Giants travel to California to take on the LA Rams. New York earned a huge win over the Cowboys in Week 1 to put the NFL on notice, while the Rams fluffed their lines as Super Bowl favorites, as they were crushed by the 49ers in Australia.

Giants vs Rams kicks off at 8:15 PM ET live on ESPN, and we've got everything you need to bet on this game in our handy betting guide. You can get our expert NFL picks on the side and total for this matchup, along with every game throughout the entire season, as well as Prop Holliday's best NFL player prop bets, JutPicks' anytime touchdown scorer predictions, and even a Giants vs Rams Same Game Parlay! Let’s break it all down.

Giants vs Rams Latest Odds

Odds courtesy of bet365 and available at 9:00 AM ET on Monday, September 21. Find out the latest NFL odds for every Week 3 matchup.

Money Line: Giants (+250) vs Rams (-310)

Point Spread: Giants +6.5 (-105) vs Rams -6.5 (-115)

Game Totals: Over 47.5 (-110), Under 47.5 (-110)

Giants vs Rams Predictions & Picks

Chris Farley’s Giants vs Rams spread pick: Rams -6.5 (-105)

After beating the Cowboys in their opener, the Giants now need to refocus and travel across the country to face an angry Matthew Stafford and company. On paper, the Rams still own one of the most impressive skill groups in the NFL. We like regression to swing this in favor of LA.

Chris Farley’s Giants vs Rams total prediction: Over 47.5 (-110)

The Giants’ defense looked good against Dallas, but they don’t know the Rams like the 49ers do. Nor does John Harbaugh. Expect Los Angeles to score immediately, which means the Giants will be chasing. If New York can get to 20, this total should soar over 50.

Read NFL pro bettor Chris Farley’s full analysis for his Giants vs Rams MNF predictions tonight, including a 5-star best bet

Giants vs Rams Player Prop Bets

Best Giants vs Rams player prop bet: Blake Corum (LAR) Over 45.5 Rushing Yards (-114)

There were very few bright spots for the Rams in Week 1, but Blake Corum stood out immediately. He was explosive and hit the gap with confidence, resulting in 10 carries for 54 yards. He should find quite a bit of success against a weak Giants interior defensive line.

Get the full analysis for Prop Holliday's best Giants vs Rams player prop bets, including another pick targeting Isaiah Likely

Giants vs Rams touchdown scorer best bet: Malik Nabers (NYG) anytime touchdown scorer (+210)

Malik Nabers is ready to be ramped up. He ran a route on just 70% of the Giants' dropbacks, but commanded a 31% target share. Look for Nabers to spark an offense that has limited weapons outside of him and Isaiah Likely.

After a +280 winner on SNF, don't miss JutPicks' Giants vs Rams TD scorer best bets, including another pick at +400 odds!

New York Giants vs LA Rams Same Game Parlay

Rams -6.5 over Giants (-115)

The Giants looked good against the Cowboys, but their sample size of success remains small. Let’s not anoint John Harbaugh as the greatest thing since sliced bread and his team as Super Bowl champions just yet. It would be no surprise if the visitors get a wake-up call in LA.

Davante Adams to Record 70+ Receiving Yards (+118)

Although the Giants’ defense fared well enough in Week 1, they were nothing special against the pass in 2025. Matthew Stafford should be able to throw for plenty of yards, and – especially if Nacua is out of the mix – Adams will be a beneficiary.

Isaiah Likely Over 44.5 Receiving Yards (-112)

Harbaugh was not the Giants’ only offseason acquisition from Baltimore. Likely also came along, and dividend payments were immediate. The fifth-year tight end out of Coastal Carolina caught eight balls for 78 yards and two touchdowns during his debut with his new team in Week 1. Returns are early, but it would be no surprise if Likely is solidly New York’s #2 receiving option behind Malik Nabers throughout the season.

Giants vs Rams SGP odds: +625

Wrap up NFL Week 2 and start the new week in style with our expert's Giants vs Rams Same Game Parlay Picks for MNF

NFL Week 3 Picks

Keep an eye out for our expert NFL predictions for every Week 3 game as they are added throughout the week!