NFL Week 2 5-Leg Parlay: Best Picks for Sunday's Games at +1750 odds
Week 1 of the 2026 NFL season featured plenty of offense, which was a start change from seasons' past. This week, we've already seen the Detroit Lions and Buffalo Bills treat us to a display of fireworks, to the tune of a combined 72 points. Will Sunday's massive slate of games bring more offense? Or, will the defenses fight back after a brutal Week 1 for defensive coordinators across the league.
With the 2026 campaign moving into its second week, let’s get right into my NFL Week 2 parlay that pays out at over 17/1 odds at FanDuel Sportsbook, and don't forget our NFL predictions for tips and analysis on every game throughout the season.
Bears team total over 26.5 (-115)
Ravens first half -5.5 (-115)
Bucs ML (-450)
Jaguars ML (+126)
Colts vs Chiefs Under 46.5 (-158)
NFL Week 2 parlay odds: +1750
NFL Parlay Pick: Chicago Bears team total over 26.5 (-115) over Minnesota Vikings
While it's important not to overreact to Week 1, this is actually an instance where I believe that the market isn't reacting quite enough to what we saw from the Bears a week ago. Ben Johnson said that the Bears are attempting to be the highest scoring offense in league history, and his team certainly looked the part in Week 1 — putting up 59 points in a dominant victory over the Panthers. Chicago’s offense needed to hang a big number because the Bears’ defense allowed 37 points of their own, and that could be a theme for the rest of the season. Add in the fact that the Vikings defense allowed plenty of explosives to Jordan Love and the Packers last week, and it wouldn't shock me if Brian Flores' aggressive nature burns him on Sunday against a quarterback and play-caller of this caliber.
Grab our expert’s best bets for NFL Week 2
NFL Parlay Pick: Baltimore Ravens first half -5.5 (-115) over New Orleans Saints
The Saints are getting a fair bit of respect in the market following their impressive showing in Detroit a week ago. However, one thing New Orleans has consistently struggled with in recent seasons is starting slow. We just saw the Saints fall behind 21-0 a week ago, and this group was just 4-12 against the spread in the first half under Dennis Allen in 2025. Conversely, the Ravens have historically been an elite team in the first half with Lamar Jackson at the controls (60% ATS for his career), and this has been a wager that I've targeted plenty over the years. Furthermore, this will be the toughest defense that Tyler Shough has faced in his young career as an NFL starter, which inspires even more confidence in a quick start for Baltimore on Sunday.
NFL Parlay Pick: Tampa Bay Buccaneers ML (-450) over Cleveland Browns
For the next leg in my mega parlay, I'm going to use the Buccaneers as an anchor leg as a significant home favorite. Much has been made of the fact that Tampa Bay has not covered the spread in 10 straight games dating back to last season, but we don’t need the Buccaneers to win by margin on Sunday. The market has downgraded Cleveland significantly following an abysmal showing in Week 1, but it’s still not quite enough in my eyes — certainly as long as Deshaun Watson is the quarterback leading this offense. All things considered, Tampa Bay was pretty unlucky to not even cover the number against the Bengals a week ago — largely due to losing four fumbles — and the Bucs should get back into the win column at home with a victory over the Browns.
Don't miss our NFL expert’s best anytime touchdown scorer bets for Week 2
NFL Parlay Pick: Jacksonville Jaguars ML (+126) over Denver Broncos
These teams appear to be trending in different directions at the moment, and I'm going to side with a Jacksonville team that picked up right where it left off at the end of last season. The Jaguars have been on an absolute tear in the regular season dating back to the second half of last year, and that continued with a dominant victory over the listless Browns in Week 1. Trevor Lawrence played an excellent game once again, and he's now ranked first in touchdowns, first in passing rating and fourth in passing yards over this nine game winning streak. On the other side, Denver appears to be heading for a bit of a regression season after feasting on a number of mediocre and/or bad quarterbacks in 2025. Bo Nix was a mess in last week's game against Kansas City, and I'm not sure why that would change all that much this week — especially with the pressure to keep up with this Jaguars offense.
Catch our full Jaguars vs Broncos prediction
NFL Parlay Pick: Indianapolis Colts vs Kansas City Chiefs Under 46.5 (-110)
The Colts defense was a nightmare against the Ravens a week ago, but Indianapolis is playing an offense this week that is a lot less explosive than what they saw against Lamar Jackson, Derrick Henry and company. While we did see some explosive runs from Kenneth Walker in Week 1, the Chiefs ground attack in that game was still worse than last year on a down-to-down success rate basis in that game. With that in mind, this is not nearly as tough of a matchup for the Indianapolis defense as the market expects. On the other side of the ball, Daniel Jones is certainly not a threat to run at the moment and if he’s unable to use his legs, this Colts offense is in real trouble. Add in the fact that the Kansas City defense appeared to be on the right track to finding its previous form following a bad 2025 season, and you have a recipe for another Chiefs under in primetime.
Get our full Colts vs Chiefs predictions
