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NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +21.7 units of profit, from 105 winning ATS picks so far this season is the proof.

Our NFL picks this week include against the spread picks for every game in week 14, highlighted by Cowboys vs Lions on Thursday Football, Texans vs Chiefs on Sunday Night Football and Eagles vs Chargers on Monday Night Football.

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8:15 PM ET
Thu Dec 4
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Dallas Cowboys
Detroit Lions
Cowboys
Lions
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Point Spread Pick
DAL Cowboys +3.0(-105)

Perceptions have never been higher on the Cowboys. One week after knocking off the Eagles, a game that sent Philly’s hopes into a spiral, Jerry Jones’ franchise beat the Kansas City Chiefs, cementing victories against each of last year’s Super Bowl attendees. Dallas’ Thanksgiving win might’ve been more impressive than their Week 13 takedown of the Eagles since it included more big plays from their defense. Obviously a different group than the bottom-feeders that started the season, the Cowboys’ defense held Kansas City to just 6 yards per play and 5-13 on third downs.

Fresh new faces this season made impacts throughout the game, including two sacks by Jadeveon Clowney, one by Dante Fowler Jr., and others made key stops when it mattered. Their offense continued to show off, too. Against one of the best defenses and best defensive coaches in the NFL, Dak Prescott avenged an early interception to go 27/39 for 320 yards and two touchdowns. The bulk of that production came from his two all-world receivers, George Pickens and CeeDee Lamb, who combined for 13 catches, 200 yards and a touchdown. Their ground attack also continued to exceed expectations (26 carries for 137 yards), good for 5.3 yards per carry.

Perhaps most important of all, Cowboys’ coach Brian Schottenheimer was in full command against the three-time Super Bowl winning Chiefs, out-witting Steve Spagnuolo in key moments of the game. At 6-5-1, Dallas is in position to threaten for an NFC East crown, believe it or not!

Things didn’t go so smoothly for the Lions on Thanksgiving. Just like two seasons ago, they allowed Jordan Love and an upstart Packers’ offense to slice through their resistance when it mattered. Green Bay threw for 7.8 yards per pass and eventually put up 31 points, and then their defense shut down the Lions’ offense in the fourth quarter. It was a startling showing from Dan Campbell’s program, an outfit we expect to show up and play elite football in these spots. Even worse, Detroit has key injuries throughout their offense. Amon-Ra St. Brown is officially a game-time decision on Thursday, Detroit is down to their third tight end, and center Graham Glasnow remains out.

Our first inclination was to go with Detroit off a loss, at home, and with increasing desperation to get their season back on track. But there’s too much momentum on Dallas’ side right now, and we’re not sure how the Lions will be able to stop Dak and his first-class offense (4th in EPA per pass). We’ll go with the visitors.

Cowboys vs Lions TNF prediction: Cowboys +3 (-105) available at time of publishing. Playable at that number.

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Game Totals PickBest Bet
Over 53.5(-120)

The obvious approach in a game with two offenses as potent as the Cowboys and Lions is to consider the over. Markets obviously know that. Even at opening, this total was far above average and has barely budgeted, now circulating around 53.5 depending on the book. Both programs have shown impressive defensive performances at various junctures this season, but for the most part Dallas and Detroit are well below the mean on that side of the ball.

For example, although they’ve played better recently, the Cowboys rank bottom five in opponent points per game and points per play and in opponent yards per game in yards per play. Lately their defense has been aided by new additions Quinnen Williams and Logan Wilson, who coincidentally arrived around the same time that Dallas’ defensive roster got healthier. That helped their resistance limit the Raiders to 16 and the Eagles to 21 points, but last week they still permitted 28 to the Chiefs, a team far more comparable to the high-powered Lions.

It’s tough to not be disappointed by Detroit’s performance last Thursday, but one must keep in mind that it was against a tough divisional opponent. Green Bay seems to have Detroit’s number. Dallas can say no such thing. Last season the Cowboys allowed a similarly constructed Lions’ roster to put up 47 points at AT&T Stadium. This Thursday Detroit is surely incurring some injury problems, but they should also be hyper-motivated to correct their mistakes, especially since the NFC North crown is at risk of slipping away. And as most know, the Lions depend on their offense to carry them to victory (they’re top three in points and yards per game).

We could get cute here, but we must take the over.

Cowboys vs Lions best bet: Over 53.5 (-120) available at time of publishing. Playable to 54.5.

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Why Trust our NFL Picks

Through week 13 of the 2025 season our team of NFL handicappers have made against the spread and totals picks for every game. with 105 wins (and 2 pushes) our record speaks for itself. Our expert NFL picks against the spread have scored +21.7 units of profit so far this season.

WinsPushLossesProfit (betting units)
105285+21.7

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

  • The team that covers the spread wins the game outright around 80% of the time.
  • Road teams going into games as the favorite have covered the spread at 64% so far this season
  • Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

  • Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
  • Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
  • Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

  • Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
  • Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
  • Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule 

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season. 

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

 

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.