1
BetMGM
1
Caesars Sportsbook
1
bet365
1
DraftKings
1
FanDuel Sportsbook
1
Fliff Social Sportsbook
1
High 5 Casino
1
Sportzino
1
Pulsz
1
WOW Vegas
1
McLuck
1
Hello Millions
Fanatics Sportsbook
(5/5)
Bet and Get up to $2,000 in No Sweat Bets FanCash
Bonus Value
$2,000
T&Cs apply. 21+ Gambling problem? Call 1-800-GAMBLER

NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +25.7 units of profit, from 177 winning picks so far this season is the proof.

Our NFL picks this week include against the spread picks for every game in week 12, highlighted by Bills vs Texans on Thursday night football, Buccaneers vs Rams on SNF and Monday Night football, featuring Panthers vs 49ers.

Read More
Filter Picks
Filter Picks
Bet Type
Experts
Confidence Rating
8:15 PM ET
Today
ESPN
Carolina Panthers
San Francisco 49ers
Panthers
49ers
View Preview
Point Spread PickBest Bet
SF 49ers -6.5(-115)

Markets and NFL media heads are high on the Panthers after they did something highly unusual: win a big game on the road with Bryce Young under center. Even more unusual was Young’s form. The former Alabama star made Panthers history last Sunday, throwing for a franchise game-high 448 yards and 3 touchdowns in a winning effort at Atlanta. Down 21-10 at halftime, at one point Young had to exit to Carolina’s locker room to address a new ankle injury. Immediately it felt like the same old story; an ailing group under new coach Dave Canales — who can’t quite get it right. The Panthers’ offense caught fire, along with their defense permitting just 92 yards and 6 second-half points. History will see Week 11 as an impressive comeback win for Canales’ group, a roster that’s proving it’s not built the same as previous iterations.

Unfortunately, we’re here to spoil the party. While the Panthers win was impressive, we must consider their opponent. After starting the season looking like a formidable NFC contender, the Falcons loss on Sunday was their fifth in a row. Even worse, Michael Penix Jr., their second-year starter who took over for Kirk Cousins last season, left with what’s likely a season-ending knee injury. Atlanta’s defense has also been floundering for over a month. This Sunday Carolina will face a much bigger road challenge. The 49ers are coming off an inspiring victory on Sunday, one that left their fans hopeful that this season may have a higher ceiling than once thought. San Francisco leveraged 3 Arizona turnovers, but with Brock Purdy back the offense was smooth and explosive — turning 5 red-zone possessions into 4 touchdowns. The Niners clobbered their rivals 41-22 on their enemy’s home field, and — perhaps most importantly — Purdy looked fantastic (19-for-26, 200 yards, 7.7 yards per pass, 3 touchdowns). It was the kind of win that catalyzes future success.

The Panthers deserve a ton of credit for their turnaround this season, but the 49ers still have championship fabric throughout their roster — including a coach and quarterback pairing who are as effective as any in the NFL. The Niners’ offense is also healthier than it’s been all season, with Jauan Jennings, Ricky Pearsall and George Kittle all ready to roll for Week 12. I like the home team to pull away.

Panthers vs 49ers best bet: 49ers -6.5 (-115) available at time of publishing. Playable to 7.

You can bet on our Panthers vs 49ers pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!

BET -7.0 NOW WITH
Game Totals Pick
Over 48.5(-115)

We should start by stating the obvious: no NFL team has more overs this season than the San Francisco 49ers. They are 7-3-1 to the over through 11 weeks. Of course, part of that is because of their litany of defensive injuries. Entering Week 12, they have 6 defensive players on injured reserve — including their 2 best players, Nick Bosa and Fred Warner. Because of those injuries they have consistently allowed points (22.9), but their offense is a big part of it, too. Whether it was Brock Purdy or Mac Jones, their offense continues to be productive. After all, it is run by Kyle Shanahan — widely regarded as one of the NFL’s best playcallers. The Niners have gained 349.4 yards per game, a top-10 mark, and now that their playmakers are healthy their average points are bound to rise (currently 23.7 per game, 15th). 

The Panthers’ offense is unlikely to perform as well as they did this past Sunday (30 points, 486 yards), but they can still do some damage on Sunday. The Niners’ defense simply hasn’t been very good regardless of who has been on the field. According to advanced EPA metrics, they are 31st in defensive success rate and 26th in EPA per play. They have also allowed 114 points in their past 4 games. I don’t necessarily expect Bryce Young to have a repeat performance in the Bay Area this Sunday, but the Niners’ secondary is a bottom-5 program in EPA per pass. Plus, Young’s Week 11 showing should only produce more confidence. They can surely get into the 20s.

Panthers vs 49ers prediction: Over 48.5 (-115) available at time of publishing. Playable to 49.5.

Bet like a Caesar with this AMAZING new customer offer from Caesars Sportsbook. If you bet just $1, you’ll receive DOUBLE YOUR WINNINGS on your next 20 bets! Become a Caesars member 👥 using the Caesars promo code PWCONTENT20X, where you can bet on our Panthers vs 49ers picks.

BET o48.5 NOW WITH
Chris R. Farley

Why Trust our NFL Picks

Through week 11 of the 2025 season our team of NFL handicappers have made against the spread and totals picks for every game, with 177 wins (and 3 pushes) our record speaks for itself. Across these markets our expert NFL picks have scored +25.7 units of profit so far this season.

NFL PicksWinsPushLossesProfit (betting units)
Sides (Moneyline & ATS)90271+20
Totals (Over/Under)87175+5.7
All Picks1773146+25.7

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

  • The team that covers the spread wins the game outright around 80% of the time.
  • Road teams going into games as the favorite have covered the spread at 64% so far this season
  • Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

  • Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
  • Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
  • Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

  • Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
  • Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
  • Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule 

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season. 

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

 

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.