NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +27.2 units profit, from 238 winning NFL picks so far this season is the proof.

Our NFL picks this week include against the spread picks for every game in week 16, highlighted by an all-NFC West Thursday Night Football when the Rams take on the Seahawks. Sunday Night Football will see the Patriots travel to Baltimore to face the Ravens and on Monday Night Football it’s 49ers vs Colts.

The Playoffs are now just around the corner, and both qualification and seeding is still undecided for many teams. Bears vs Packers and Buccaneers vs Panthers are the divisional matchups with the most on the line, and therefore also not to be missed.

Filter Picks

8:15 PM ET

Tomorrow

Amazon Prime

Rams

Seahawks

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Money Line Pick

SEA Seahawks Win(-108)

Reasoning

Evidently both the Rams and Seahawks were mentally distracted in Week 15 since neither outfit put out their best performance, but one certainly played better than the other. The Rams started slow against the Lions, tied at halftime 17-17. Then they took off, scoring 17 unanswered points in the third quarter while cruising in the fourth. Even in a high-stakes, emotional battle, Matthew Stafford and his colleagues had no problem moving the ball against a fiery, motivated Lions’ roster. Los Angeles accrued 514 total yards and 30 first downs. They also scored a touchdown on four of six red-zone possessions. It was ultimately another sterling performance by a group that’s as intimidating as any in the NFL. An asterisk from the Week 15 victory was the unfortunate loss of Devante Adams, who incurred a hamstring injury. He’s unlikely to play Thursday, which is a big loss, especially near the endzone (Adams has a league-high 14 receiving touchdowns this season).

The Seahawks were clearly looking ahead to this heavyweight matchup in Week 15. Sam Darnold and the offense generally underwhelmed, producing just 18 points, 314 total yards, and 15 first downs. The Colts’ defense came to play, as did the Seahawks, who allowed just 3.7 yards per play and 215 total yards to the Phillip Rivers’ led visitors. The Seahawks defense has an edge in Week 16, since they outrank the Rams in both EPA per pass (5th) and EPA per rush (1st).

Los Angeles and Seattle will enter Week 16’s showdown with 11 wins each, competing not only for the NFC West crown but potentially for the #1 seed in the conference. In that sense, this is akin to a playoff matchup, with much riding on the result. Normally we side with the more experienced leadership in those instances, which means typically we’d pick Super Bowl winning coach Sean McVay and Matthew Stafford. But these circumstances are a bit different.

In a “prove-it” game, Darnold and the offense collapsed in Week 11. Although they gained plenty (414 yards), Darnold threw four interceptions, stonewalling several trips in the red-zone (they were just 1-4). But statistically the Seahawks outmatched the Rams in nearly every category except turnovers, including a 26-12 lead in first downs and better efficiency on third downs, too (7-16 compared to LAR’s 2-11). Los Angeles also went scoreless in the third and fourth quarters, held in check by a stingy Seahawks’ defense. Back in Seattle and with vengeance adding extra motivation, we must side with the home team.

Los Angeles Rams vs Seattle Seahawks prediction: Seahawks ML (-108) available at time of publishing. Playable at that price.

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Game Totals Pick

Over 44.5(-104)

Reasoning

In their first battle the Seahawks left a ton of points on the board. In short, game one ended up being an odd, low-scoring affair (40 total points), so naturally the marketplace thinks it’ll be a repeat with the division and possibly #1 seed on the line. We disagree. Seattle produced a ton of offense in the initial clash (414 total yards, 26 first downs), but turnovers upended many of their drives. Sam Darnold threw four interceptions, easily his most mistake-prone performance of the season. The Seahawks are also coming off a clunky offensive showing (18 points in Week 15), but it’s not their norm. This season they’ve averaged 27.7 points per game at Lumen Field, and it’s likely they discarded preparation for the Colts with this big clash ahead.

The Rams’ defense is one of the best in the NFL according to some metrics, mainly EPA, but we’ve seen cracks in the foundation at times, especially against elite offenses. Last week they allowed 34 points to the Lions at home, for example. The Rams’ defense also doesn’t have “that guy” yet, and they’re a young group, which means they’re prone to mistakes in these big spots.

Of course, the Rams are one of the NFL’s best offenses by nearly every metric, so we’re less concerned there. Even their rushing attack has come around, ranked 8th overall in EPA per rush. They’ll need it against the NFL’s best run-resistance. The Rams will likely be without Devante Adams on Thursday, who suffered a hamstring injury against the Lions, but Matthew Stafford and his surrounding cast have enough talent to make up for his loss. We get why the market thinks a big NFC West battle will conjure more defense, but we still have to side with these two scintillating offenses. The second half should be particularly potent, once both quarterbacks settle in.

Los Angeles Rams vs Seattle Seahawks prediction: Over 44.5 (-104) available at time of publishing. Playable at that number.

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Vote on who will win!

8:20 PM ET

Sun Dec 21

NBC

Patriots

Ravens

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Point Spread PickBest Bet

NE Patriots +3.0(-115)

Reasoning

For the first time all season, the Baltimore Ravens finally had an easy win in week 15. Of course, Cincinnati seemed deflated from the very start of last week’s game, and a Joe Burrow lead offense was out of its rhythm, failing to score a single point. The ravens deserve credit all around, they showed up and got the job done and they must-win situation, but it still doesn’t improve that their struggles have ceased. We also can’t dismiss that Baltimore still ranks a lowly 20th in total offensive EPA metrics, and they’re not much better on defense either (16th). Their secondary is even more concerning, ranked 19th in defensive EPA per pass and permitting 233.3 passing yards per game (26th). Even worse, only the 49ers sack the quarterback less (Baltimore ranks 31st, taking down the quarterback on only 4.14% of plays). We hate that for their matchup on Sunday night.

There is no reasonable evidence that suggests the Ravens are a better team than the Patriots entering Week 16. Baltimore’s edge is that they’re at home and that they have more experience in big-time matchups like this, a cyclical playoff participant under the era of John Harbaugh and Lamar Jackson. But when it comes to this season, the Patriots are the better team in every category. Offensively they rank 6th in total offensive EPA and 12th in total defensive EPA, not to mention they’re coming off a 10-game winning streak, which was broken in Week 15.

Speaking of Week 15, we’re not concerned about the Patriots because of one flawed half. Many teams fall victim to the magic of Josh Allen, who engineered yet another second half comeback last Sunday. New England showed its youth and inexperience last weekend, but otherwise they’ve been one of the most consistent programs in the NFL. In fact, only the Seahawks and Rams, two other 11-3 outfits, have a better point-differential than Mike Vrabel’s team (+7.6).

Especially since they’re coming off a loss, there’s simply no way we could bet on the Ravens here. Too many times we’ve seen their defense capitulate, and even in an easy win last week, their offense was rather pedestrian (317 total yards, 15 first downs). Meanwhile, the Patriots have been a well-oiled machine and one of the best ATS teams all season (8-5-1, 61.5%). If we’re getting a field goal with the visitors, we’re taking it.

New England Patriots vs Baltimore Ravens: Patriots +3 available at time of publishing. Playable at that number.

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Game Totals Pick

Over 48.0(-110)

Reasoning

This total is curiously high. Maybe part of that is because Baltimore will be unseasonably mild and calm on Sunday night, forecasted to be in the mid-40s, a perfect night for football. Perhaps it’ll become a perfect night for scoring, too. The market is certainly sending a signal by posting this above 47, a prime key number in totals.

Matchup wise, it makes sense. New England’s defense has mostly been very good this season, but they’re also coming off a contest where they were exposed by a dynamic quarterback. Perhaps no NFL quarterback is as dynamic as Lamar Jackson, a true outlier athlete with a legitimate rifle of an arm to boot, very Josh Allen-like. The market is likely responding to the fact that New England’s schedule has featured very few top-tier offenses. In fact, according to EPA metrics, they’ve only clashed with two top-15 offenses this season (BUF, PIT). Despite Baltimore’s transgressions this season, they can overwhelm any defense when functioning at a high level.

The Patriots’ offense needs no introduction at this point, nor does that missteps of the Ravens’ defense. Defensively, Week 15 was easily Baltimore’s most impressive showing all season, blanking the Bengals and holding Joe Burrow and company to only 298 total yards. Despite holding the ball for nearly two-thirds of the game (39:19), Cincinnati went 3-15 on third down conversions, too. Still, we haven’t seen that version of the Ravens’ defense for any consistent stretch all year, a group that permits 344.4 yards per game (23rd). Both offenses are in a good spot and we trust both teams to rely on their production in this huge Sunday night game. We can only look at the over.

New England Patriots vs Baltimore Ravens prediction: Over 48 (-110) available at time of publishing. Playable at that number.

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Why Trust our NFL Picks

Through week 15 of the 2025 season our team of NFL handicappers have made against the spread and totals picks for every game. with 238 wins (and 3 pushes) our record speaks for itself. Our expert NFL picks have scored +27.2 units of profit so far this season.

NFL Pick	Wins	Push	Losses	Profit (betting units)
Sides (Moneyline/ATS)	121	2	99	+23.4
Totals (Over / Under)	117	1	103	+3.8
Total	238	3	202	+27.2

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

NFL spread betting trends 2025

The team that covers the spread wins the game outright around 80% of the time.
Road teams going into games as the favorite have covered the spread at 64% so far this season
Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

NFL over / under betting trends

Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

NFL Moneyline betting trends

Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season.

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

How Do You Pick Against The Spread In The NFL?

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

What Is The Best Website For NFL Picks Against The Spread?

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

Where Is The Best Place To Get NFL Picks?

Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.