Arizona Cardinals vs Tampa Bay Buccaneers Prediction, Odds and Picks for Today, 11/30/25

This pick, too, is obviously dependent on Mayfield taking the field. Assuming he does, my Cardinals vs Bucs pick is Over 44.5. Tampa Bay is also finally welcoming back RB Bucky Irving. Aside from Mike Evans’ continued absence, the Bucs’ offense is close to being fully loaded (aside from the fact that Mayfield surely won’t be 100 percent). Only 3 times in 11 games this season have the Bucs been held to fewer than 23 points. With Irving back, the home side should once again put up some decent numbers against a reeling Arizona defense. The Cardinals have allowed 44, 41 and 27 points over the past 3 weeks.

Fortunately for the visitors, Brissett has been balling. The 32-year-old boasts an 11-to-3 touchdown-to-interception ratio so far in 2025 and has passed for at least 258 yards in all 6 of his starts. That includes performances of 317, 320 and 452 yards. He now faces a Tampa Bay defense that ranks #27 against the pass (243.5 yards per game allowed) and #29 in yards per pass attempt allowed (7.6). These 2 teams are #26 (Tampa Bay) and #25 (Arizona) in scoring defense. Let’s go with the over.

Arizona Cardinals vs Tampa Bay Buccaneers prediction: Over 44.5 (-110) available at time of publishing. Playable at that number.

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