Atlanta Falcons vs San Francisco 49ers Prediction, Odds and SNF Picks for Today, 10/19/25

This is the definition of a regression game on both sides. We’ll start with the 49ers. San Francisco will be coming off a tough loss at Tampa in Week 6 but they have plenty to hang their hats on. Veteran all-pro linebacker Fred Warner sustained an injury early in the game and Mac Jones threw 2 interceptions, but the visitors were still in a one score game entering the fourth quarter. The Bucs did a nice job closing it out late, but it was largely an even matchup. For example, San Francisco gained 363 yards while Tampa gained 352. Despite their many injuries on both sides of the ball, the 49ers went toe-to-toe in enemy territory with one of the best teams in the NFL. I left feeling better about their potential this season, regardless of the dwindling health of their roster.

This Sunday sets up beautifully for a redemption spot. Early in the week, reports out of the 49ers camp suggest that George Kittle, Brock Purdy and Ricky Pearsall are all trending toward playing on Sunday night. Kittle has the most challenging journey to return, since his 12 day practice window just opened following 4 weeks on the injured reserve. Heading back home following a disappointing loss, San Francisco will take any healthy returning player that they can get.

The Falcons did nothing but impress in their Week 6 victory over the Bills on Monday Night Football, but there is also some reason to believe it was fluky. Firstly, the game started on a Bijan Robinson fumble and Bills’ recovery, but Buffalo was offside and it negated the turnover. The Bills also have serious issues with their run-defense, so predictably they were overwhelmed by Robinson and Tyler Allgeier — arguably the best rushing-duo in the NFL. The 49ers don’t have the same issues, ranking 12th in yards per carry allowed. Atlanta mostly won via big plays in their ground attack, with Robinson and Allgeier galloping down the sidelines on seemingly every possession. We doubt their offense can be that simple and still experience the same success against an above-average defensive coordinator in Robert Saleh. This fits a pattern we love; an overconfident team on the road following a strange win against a home team getting healthier and historically more buttoned up than the opponent. The value is clear.

Atlanta Falcons vs San Francisco 49ers prediction: 49ers -2 (-110) available at time of publishing. Playable to -2.5.

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