Buffalo Bills vs Carolina Panthers Prediction, Odds and Picks for Sunday, 10/26/25

Buffalo is back from the bye week looking to get on track following consecutive losses to New England and Atlanta. The Bills, who started the season at 4-0, are now sitting in second place of the AFC East behind the 5-2 Patriots. Buffalo heads to Carolina to face the Panthers, who are set to start veteran Andy Dalton at QB in place of the injured Bryce Young. The Panthers began the season with road defeats at Jacksonville and Arizona, but Carolina stormed back with four wins in the last five games. Carolina owns a perfect 3-0 home record this season and held off the winless Jets, 13-6 at Met Life Stadium last Sunday. Young sustained a right ankle injury in the third quarter and was replaced by Dalton, who threw for 60 yards in relief.

The Bills are 0-4 ATS in their last four games, coming off the 24-14 Monday night loss to the Falcons in Week 6. QB Josh Allen has thrown multiple TD passes in four consecutive games, but last season’s MVP has been intercepted three times in the past two losses. In both road games, Allen has completed 56.9% of his passes, compared to 73.2% of his attempts at home.

Buffalo has lost four of its past six away games since last December, while Carolina is 4-0 in its previous four home contests. Dalton won his first start with the Panthers last season, but proceeded to drop his next four games before Young returned to the lineup. Buffalo ranks third in the NFL in yards per game at 378.3, while Carolina is seventh defensively in yards allowed at 295.7 per game. Carolina has been an underdog in all three home games and were close to losing twice to Miami and Dallas. Buffalo will be a public play here but it’s hard to think the Bills won’t be ready off the bye week trying to snap a two-game slide against a veteran backup at quarterback for Carolina.

Bills vs Panthers prediction: Bills -7 (-115) available at time of publishing. Playable to 8.

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