Buffalo Bills vs New York Jets Prediction, Odds and Picks for Sunday, 09/14/25

It will be a showdown in the AFC East when the Buffalo Bills visit the New York Jets in Week on Sunday afternoon. That Buffalo is 1-0 and New York 0-1 is hardly surprising, but both season-opening games were quite unexpected — albeit for different reasons. The Bills engineered an incredible comeback to beat the Baltimore Ravens 41-40, while the Jets lost a shockingly high-scoring game against the Pittsburgh Steelers 34-32. Now, who are the real Bills? Are they the ones who were getting beat out of their own building for 3 quarters? Or are they the ones who took charge against arguably the best team in football when it mattered most? The consensus is that it’s the latter, and there is no reason to disagree with that notion. There are a lot more reasons to believe in the Bills than not, so my Bills vs Jets prediction is on the visitors to win and cover.

Quarterback is obviously the most important position sports, and Buffalo definitely has a significant advantage in that department on Sunday. In fact, it might have it in every game it plays this season. Josh Allen is the reigning MVP and sure looked the part in leading his team back from the brink against Baltimore. Justin Fields also impressed in his Jets debut, but the sample size of his success is obviously a lot less than that of Allen. Whatever the case, Fields is the least of New York’s concerns. Giving up 34 points to 41-year-old Aaron Rodgers and a ragtag Pittsburgh outfit is extremely alarming. If you’re letting Rodgers go 22-of-30 for 244 yards, 4 scores and zero interceptions even when you can drop back in coverage knowing that his team can’t run the ball, you have serious defensive problems. Just imagine what Allen can do to the Jets if Rodgers is doing that? I don’t think the Jets can score enough to stay within a touchdown of Buffalo’s offense.

Buffalo Bills vs New York Jets prediction: Bills -6.5 (-110) available at time of publishing. Playable at that number.

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Both of these offenses went wild in Week 1. I think they can do similar damage on Sunday, so my next Bills vs Jets pick is Over 45.5. In fact, Buffalo could get close to this number by itself. Obviously you would think New York’s defense will play better–or “less bad”–than it did the season offense, but keep in mind that it is now facing a much more dynamic offense than that of Pittsburgh. It’s not just Allen, either. James Cook scored once on the ground and Keon Coleman showed signs of breaking out in year 2 with 8 receptions for 112 yards and 1 TD.

Meanwhile, Fields torched a TJ Watt-led defense for 3 touchdowns (1 passing, 2 rushing). Breece Hall finished with 145 yards from scrimmage and the Jets averaged 6.4 yards per play. Now they face a Buffalo defense that allowed Baltimore to average a laughable 8.4 yard per play. The Bills got lucky when Derrick Henry fumbled late in the fourth quarter, but otherwise they had no chance of stopping either him or Lamar Jackson. Let’s back the over — and do it with a fair amount of confidence.

Buffalo Bills vs New York Jets prediction: Over 45.5 (-115) available at time of publishing. Playable to 46.5.

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