Chicago Bears vs Detroit Lions Prediction, Odds and Picks for Sunday, 09/14/25

It may be too early to say that 2 teams are in a must-win spot, but the loser of this Chicago/Detroit matchup falls to 0-2 overall and 0-2 in division play. The Lions’ offense certainly looked different after offensive coordinator Ben Johnson left to take the head coaching job in Chicago. Detroit lost at Green Bay 27-13 as the lone touchdown came in the final minute of regulation. QB Jared Goff completed 31 passes but totaled 225 yards for the Lions, while the running game was held to 46 yards.

The Bears blew a 17-6 lead in the 4th quarter on Monday night in a 27-24 home setback to the Vikings. QB Caleb Williams threw for 210 yards and rushed for 58 yards, but Chicago’s offense scored 1 touchdown in the final 3 quarters. The Bears picked off Minnesota QB J.J. McCarthy and returned the interception for a score to grab a 17-6 advantage before the Vikings’ rally.

Now, Johnson takes the Bears into Ford Field in this critical divisional matchup trying to beat the offense he helped lead the last 3 seasons. Chicago finished last season with a 1-7 record on the road that extends to 2-12 dating back to 2024. Detroit went 7-2 at home in the regular season before losing to Washington in the divisional playoffs. The Lions captured each of the 2 meetings last season, even though Detroit edged Chicago 23-20 at Ford Field as 10-point favorites on Thanksgiving. In the 2 matchups, Williams put up 5 touchdown passes and 0 interceptions. There will no doubt be a lot of public sentiment for the Lions, but the Bears are worth a strong look in spite of the tough Monday night loss to Minnesota.

Bears vs Lions prediction: Bears +6 (-110) available at time of publishing. Playable to 4.5.

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Chicago was on its way to an Under in the season opener against Minnesota before yielding 21 points in the 4th quarter of a 27-24 loss on Monday. The game finished Over the total of 43.5 points, even though the Vikings picked up 254 yards of offense. Detroit wasn’t close to hitting the Over in its Week 1 loss at Green Bay, 27-13 on a 48.5 total. The Lions scored their only touchdown in the final minute, while both Detroit and Green Bay each racked up less than 270 yards of offense.

Last season, the Bears went 6-2 to the Under on the road last season, while scoring 16 points or less 6 times. The Lions finished Under the total in each of its first 2 home games in 2024, but Detroit went 6-2 to the Over in its final 8 contests at Ford Field. The NFC North rivals went Over and Under the total in their 2 matchups last season. Detroit edged Chicago on Thanksgiving, 23-20, to stay Under the total of 47.5 points. In the 2nd meeting at Soldier Field, the Lions crushed the Bears, 34-17, to go Over 47.5 points. 3 of the last 4 meetings at Ford Field have gone Under the total dating back to 2021.

In the 2 meetings last season, the Bears were held to 78 and 59 rushing yards. Chicago picked up 119 yards on the ground in the loss to Minnesota, as Caleb Williams was responsible for 51 of those yards. Goff torched the Bears for 5 touchdown passes in the 2 victories last season. In his last 2 home games against the Vikings in Week 18 and the Commanders in the divisional playoffs, Goff was intercepted a total of 5 times. Look for another low-scoring game between these division rivals on Sunday.

Bears vs Lions pick: Under 46.5 (-110) available at time of publishing. Playable to 46.

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