Cincinnati Bengals vs Denver Broncos Prediction, Odds and Picks for Monday, 09/29/25

For the 2nd straight week, Bo Nix and the Broncos fell short in a close game. In fact, all 3 of Denver’s opening contests have ended by a 1-score margin or less, averaging just a 4-point margin. On both sides of the ball, they’ve had their flaws, but it’s the offense that’s been a real disappointment so far. Bo Nix hasn’t settled in yet, ranked 28th in yards per pass (5.6) with just a 64.21% completion percentage. In some statistics, like QBR (41.8, tied for 25th), he’s one of the worst quarterbacks in the NFL. Pro Football Focus grades Nix 45th out of 47 who have played under center. 

Denver’s running game has been better, generating 5.2 yards per carry (5th) and 129 rush yards per game (8th), and their defense is still one of the top units in the NFL (especially in the red-zone, where they rank 2nd in touchdowns allowed). Fortunately, Nix and the offense will face one of the worst defenses in the NFL in Week 4. 

Cincinnati’s season is already in question thanks to yet another debilitating injury to their star quarterback, Joe Burrow, but they also don’t have the defense to pick up the pieces. After mostly looking anemic, Minnesota looked like a Super Bowl contender in Week 3, posting 352 yards and 48 points on the Bengals. Cincinnati’s offensive marks were even more concerning, earning just 3.3 yards per play, 12 first downs, and just 179 total yards. Jake Browning just doesn’t do well under pressure, hoisting up 2 more bad interceptions (he had 3 at Jacksonville the week prior, in just 1 half) and failing to find a rhythm for the entirety of the game. And the Cincinnati run-game has been virtually non-existent, gaining just 53 yards last Sunday.

Another tough road spot is exactly what the Bengals don’t need after a performance that poor, but that’s exactly what they’ll get. Cincinnati must also battle one of the NFL’s best pass-rushes, a group that already ranks 4th through 3 weeks (they earn a sack on 9.92% of plays). Nothing seems to be in the road team’s favor in this one.

Bengals vs Broncos: Broncos -7 (-120) available at time of publishing. Playable to 8.

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