Cleveland Browns vs Pittsburgh Steelers Prediction, Odds and Picks for Today, 10/12/25

Cleveland returns from London following a tough last-minute loss to Minnesota as the Browns head to Pittsburgh to face the rested Steelers. The Browns fell to 1-4 after a 21-17 defeat to the Vikings as 3.5-point underdogs. Minnesota scored with 25 seconds left as Cleveland was held to 17 points or fewer for the 5th time this season. QB Dillon Gabriel played well in his NFL debut, throwing 2 TDs, while RB Quinshon Judkins busted the 100-yard mark for the first time in his career with 110 rushing yards.

The issue is the fast turnaround from traveling overseas, taking on Pittsburgh, which was off after holding off Minnesota 2 weeks ago in Ireland. The Steelers improved to 3-1 with the 24-21 victory, as all 3 of Pittsburgh’s wins have come away from Acrisure Stadium. Steelers QB Aaron Rodgers has thrown 7 TDs and 1 interception in the 3 wins, while getting intercepted twice in the lone loss to Seattle. Cleveland’s pass defense ranks 4th in the NFL in yards allowed per game, but the Browns have intercepted only 2 passes this season.

Last season, these rivals split their 2 matchups with the home team capturing each game. Cleveland surprised Pittsburgh in a mid-November TNF thriller, 24-19, on a short Nick Chubb TD run in the final minute. In the 2nd meeting in the Steel City, Pittsburgh jumped out to a 27-7 lead and crushed Cleveland 27-14 as 6.5-point favorites. The Browns have not won at Pittsburgh since the 2020 season, dropping 3 of the last 4 meetings by double-digits. There will be a narrative that Cleveland has the quick turnaround from the London trip, as the public will likely be all over Pittsburgh in this spot. You can’t deny how strong Cleveland has been defensively, and Pittsburgh is 0-2 ATS as a favorite of at least 3 points this season. With this one expected to be a low-scoring battle, it’s worth grabbing the points with Cleveland to keep it close once again.

Browns vs Steelers prediction: Cleveland Browns +6 (-110) available at time of publishing. Playable to 4.5.

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