Denver Broncos vs Indianapolis Colts Prediction, Odds and Picks for Tomorrow, 09/14/25

One of the more intriguing games on the NFL Week 2 card comes in Indianapolis, where the Colts will host the Denver Broncos in a matchup between a couple of 1-0 teams in the AFC. Indianapolis was one of the pleasant surprises in Week 1, as the Colts dominated the Dolphins in emphatic fashion on both sides of the ball in an easy victory at home. It remains to be seen if the Colts can translate this level of success into another game, but the floor should be relatively high with Shane Steichen as the head coach and play caller for this offense. Daniel Jones has a much tougher test ahead of him this week against the excellent Broncos defense, but Denver has its own issues that it needs to sort out following a disappointing Week 1 showing against the Titans. With a strong offensive line and a talented group of skill position players, the Colts should certainly be able to move the ball at home.

As for the Broncos, Sean Payton’s offense looked completely out of sorts against Tennessee, and if it wasn’t for the Denver defense forcing Cam Ward into a number of mistakes, the Broncos could’ve easily lost their home opener. Bo Nix began his sophomore season with a horrendous showing at home, and I have little confidence that he’ll suddenly improve and increase his average depth of target against a much improved Colts defense. If the Broncos are unable to establish any sort of running game, this team could be in real trouble in what should be a close game throughout. Ultimately, I have a bit more faith in a Colts team that is well-coached on both sides of the ball and has the talent on offense to give this Denver defense some problems. This game should be priced closer to a pick ’em, so let’s take Indianapolis as short underdogs at home.

Broncos vs Colts prediction: Colts ML (+110) available at time of publishing. Playable to +100.

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Unders were the prevailing trend in Week 1, and I expect that to continue on Sunday, particularly in a game featuring these defenses. Indianapolis might be one of the most improved defenses on a year-to-year basis following the insertion of Lou Anarumo as the new defensive coordinator. The Colts new hire certainly paid dividends in Week 1, as Indianapolis completely smothered the Dolphins offense last week at Lucas Oil Stadium. Now, they’ll get to tee off against Bo Nix and a Broncos offense that struggled mightily against the lowly Titans a week ago. On the other side, Denver’s defense should be one of the best in football this season, and we can expect at least a slight bit of regression from Daniel Jones and the Colts passing attack. I’ll back the under in Indianapolis.

Under 43.5 available at time of publishing. Playable to 43.