Denver Broncos vs Los Angeles Chargers Prediction, Odds and Picks for Today, 09/21/25

The Los Angeles Chargers get 3 divisional teams out of the gate and so far have picked up a pair of victories over the Chiefs and Raiders. LA seeks a 3-0 start overall and inside the AFC West with a home victory over the Denver Broncos on Sunday. The defense shut down Las Vegas on Monday night, holding the Raiders out of the end zone in a 20-9 victory as 3-point road favorites. QB Justin Herbert has thrown 5 TD passes in 2 games, including 2 against the Raiders. The Broncos took care of the Titans in the season opener, but fell apart late in last week’s 29-28 last-second defeat at Indianapolis. Following a penalty after the Colts missed the game-winning field goal, Indianapolis converted on its 2nd try to grab the victory as 1-point underdogs. QB Bo Nix threw 3 TD passes for the Broncos, 1 week after getting intercepted twice and getting held to 176 passing yards against Tennessee.

The Chargers finally play at SoFi Stadium after trips to Brazil and Las Vegas in the first 2 weeks. Los Angeles finished 5-3 at home last season, capped off by a 34-27 victory over Denver in Week 16 as the Chargers erased a 24-13 3rd-quarter deficit. The Broncos have slumped to a 1-6 mark in the past 7 road games. The lone win in this span came against the Raiders, as Denver has yielded 29 or more points in 4 consecutive away contests.

Since 2020, the Chargers are 4-1 at home against the Broncos with 3 of those wins by 7 points or less. Denver started last season at 6-1 against the spread on the road, but the Broncos have failed to cover each of their past 4 away games. The Chargers have been impressive so far through 2 games, but LA will no doubt be a huge public play on Sunday. Let’s look at the Broncos with the points on Sunday to grab the underdog cover against the Chargers and at least stay within a field goal.

Broncos vs Chargers prediction: Broncos +3 (-120) available at time of publishing. Playable at that number.

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