Denver Broncos vs Philadelphia Eagles Prediction, Odds and Picks for Sunday, 10/05/25

The Philadelphia Eagles will be looking to remain undefeated when they host the Denver Broncos in Week 5 of the NFL season on Sunday afternoon. Philadelphia (4-0) has kicked off its Super Bowl title defense with victories over Dallas, Kansas City, the Rams and Tampa Bay. Given that the Eagles are not only the superior team but also playing at the friendly confines of Lincoln Financial Field, my Broncos vs Eagles pick is on the home team to win and cover. Philadelphia is on a 10-game winning streak dating back to last season and it is 16-1 SU in its least 17 overall. It is also 5-1 ATS in its last 6, 8-2 ATS in its last 10 and 13-4 ATS in its last 17. Denver is 1-3-1 ATS in its last 4, 2-5-1 ATS in its last 8 and 0-2 ATS in its last 2 head-to-head with Philly.

Denver is winless on the road this season. In fact, its only wins have come at home against lowly opponents in the Titans and Bengals. In his second year as a pro, Broncos quarterback Bo Nix has already been picked off 4 times. The visitors now run into an Eagles defense that has 5 takeaways (3 INTs, 2 fumble recoveries). These 2 teams have squared off just twice in the past decade; Philadelphia is 2-0 with a 51-23 blowout in 2017 and a 30-13 success in 2021. This one probably won’t be quite that lopsided, but let’s back the Birds to prevail by the necessary margin.

Denver Broncos vs Philadelphia Eagles prediction: Eagles -3.5 (-115) available at time of publishing. Playable to -4.

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Even though A.J. Brown has done next to nothing this season, Philadelphia is scored plenty of points. Head coach Nick Sirianni’s team has not yet been held under the 20-point mark and it has exceeded 30 points in each of the past 2 outings. As such, my Broncos vs Eagles pick is Over 43.5. Brown is griping about his lack of production, too, so you have to think QB Jalen Hurts is going to make an extra effort to get the veteran wideout involved on Sunday. Even if that doesn’t happen, Saquon Barkley can pick up the slack in both the running and passing game. Barkley has made at least 4 receptions in 3 of the 4 games and Denver has allowed 169 receiving yards to opposing running backs.

As for the Broncos offense, running back J.K. Dobbins has stepped up amidst Nix’s relative lack of production. Dobbins has cemented himself as RB1 in Denver with 57 carries for 323 yards and 3 touchdowns. In all 4 contests so far, the former Ohio State standout has either scored a touchdown or surpassed the 100-yard mark. Meanwhile, Philly has surrendered at least 25 points in each of its last 2 games.

Denver Broncos vs Philadelphia Eagles prediction: Over 43.5 (-108) available at time of publishing. Playable to 44.

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