Detroit Lions vs Baltimore Ravens Prediction, Odds and MNF Picks for Monday, 09/22/25

You may have heard it before, but the Ravens are pretty good against NFC opponents. In the era of Lamar Jackson, Baltimore is 24-2 when the 2-time MVP starts. That’s gone on far too long to ignore, so there must be something to it. The reality is we often find Baltimore stumbling against familiar opponents like the Browns and Steelers, or the Bills (too soon?).

Against unfamiliar opponents, Jackson and his comrades seem to settle in more easily and freely in their playing style. The result has been catastrophic for their NFC foes, with the Eagles last year and the Giants 3 years ago as the only programs to overcome the juggernaut. And the Ravens often win in dominant fashion. Take 2 years ago, for example, the same season where the Lions went 12-5 and ascended to an NFC championship game. When they traveled to Baltimore in Week 7, they were decimated, 38-6. Jackson had 4 total touchdowns and 327 passing yards on just 27 attempts.

History doesn’t always repeat, but the Ravens seemed to return to form last Sunday; that’s not a good sign for Detroit. After a slow-moving first half, Baltimore dominated Cleveland and covered a 12-point spread by double digits. Their defense was particularly effective, allowing just 4.4 yards per pass to Joe Flacco. 

Of course, Detroit was even more impressive in Week 2, obliterating the hapless Bears and posting a 52-point scoreboard in a loud response to their Week 1 failure. Detroit may not be of the exact same caliber this season, but they’re still good enough to stomp on opponents at home.  On the road will likely be a different story, especially against a Ravens’ team that gets to stay in Charm City, rest and refine their product for 2 weeks leading into this battle. Detroit is an above-average team, but the Ravens are a different animal in these scenarios.

Lions vs Ravens best bet: Ravens -4.5 (-115) available at time of publishing. Playable to 5.5.

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