HomeNFLNFL PredictionsDetroit Lions vs Baltimore Ravens Prediction, Odds and MNF Picks

Detroit Lions vs Baltimore Ravens Prediction, Odds and MNF Picks for Today, 09/22/25

Updated: 9:52 AM ET Sep 22, 2025

M&T Bank StadiumABC

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Lions

8:15 PM ETToday

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Ravens

Lions vs Ravens Guest Expert Predictions

Point Spread PickBest Bet

BAL Ravens -4.5(-115)

Reasoning

You may have heard it before, but the Ravens are pretty good against NFC opponents. In the era of Lamar Jackson, Baltimore is 24-2 when the 2-time MVP starts. That’s gone on far too long to ignore, so there must be something to it. The reality is we often find Baltimore stumbling against familiar opponents like the Browns and Steelers, or the Bills (too soon?).

Against unfamiliar opponents, Jackson and his comrades seem to settle in more easily and freely in their playing style. The result has been catastrophic for their NFC foes, with the Eagles last year and the Giants 3 years ago as the only programs to overcome the juggernaut. And the Ravens often win in dominant fashion. Take 2 years ago, for example, the same season where the Lions went 12-5 and ascended to an NFC championship game. When they traveled to Baltimore in Week 7, they were decimated, 38-6. Jackson had 4 total touchdowns and 327 passing yards on just 27 attempts.

History doesn’t always repeat, but the Ravens seemed to return to form last Sunday; that’s not a good sign for Detroit. After a slow-moving first half, Baltimore dominated Cleveland and covered a 12-point spread by double digits. Their defense was particularly effective, allowing just 4.4 yards per pass to Joe Flacco.

Of course, Detroit was even more impressive in Week 2, obliterating the hapless Bears and posting a 52-point scoreboard in a loud response to their Week 1 failure. Detroit may not be of the exact same caliber this season, but they’re still good enough to stomp on opponents at home. On the road will likely be a different story, especially against a Ravens’ team that gets to stay in Charm City, rest and refine their product for 2 weeks leading into this battle. Detroit is an above-average team, but the Ravens are a different animal in these scenarios.

Lions vs Ravens best bet: Ravens -4.5 (-115) available at time of publishing. Playable to 5.5.

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Chris R. Farley

Game Totals Pick

Under 53.5(-110)

Reasoning

It would be easy to expect an Over in this matchup because of the most obvious factor: what happened last week. Baltimore and Detroit combined for 93 points against their respective opponents in Week 2. But both were against subpar defenses, and both were at home, too. We’re not suggesting the Lions can’t be productive and explosive on the road, we saw plenty of evidence of that last season (31 points per game). Then again, in their 1 road spot this season, it was less than adequate. And the Lions are different.

While a franchise like the Bears can occasionally get blown out by Detroit, better defenses may not find it as difficult opposing Jared Goff and company. The Lions lost 2 stalwart offensive linemen in the offseason. A younger, newly formed offensive line was completely dominated in Week 1 at Green Bay. Contrarily, through 2 weeks PFF ranks Chicago the 2nd-worst defense in the NFL. Last week, the Lions were super explosive (500 total yards), but they had a damn good matchup, too. Meanwhile, Baltimore’s defense ranks 3rd overall, and their front 7 is due positive regression (they’re currently 29th in sack rate). At home, Monday Night Football provides an inviting spot for that regression. Lamar Jackson and the Ravens’ offense will score, we’re bullish about that, but there’s a real chance that the Lions are greatly limited. We’ll play contrarian and side with the Under.

Lions vs Ravens prediction: Under 53.5 (-110) available at time of publishing. Playable to 51.5.

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Chris R. Farley

Chris Farley

Published: 9:52 AM ET September 22, 2025

Show Bio

Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.

@FarleyBets

Related game props

Anytime Touchdown Scorer Pick

Z. Flowers (BAL) to score a TD(+120)

Reasoning

I gasped when I found the best odds for Zay Flowers to score a touchdown against the Lions were +120. But when you look at his body of work, Flowers has been one of the most productive wide receivers through 2 weeks, and many expect that to continue on MNF with a receiving yards line of 69.5 yards. He opened the season with 143 yards on 9 targets, including a touchdown on primetime. The following week, Lamar Jackson threw his way 11 times — ranking him in the top 10 in targets and yards. In a game with a flurry of points expected to be scored, we’ll back the top pass catcher in the Ravens offense on Monday Night Football.

Detroit Lions vs Baltimore Ravens Prediction, Odds and MNF Picks for Today, 09/22/25

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