Detroit Lions vs Green Bay Packers Prediction, Odds and Picks for Sunday, 09/07/25

After a long and eventful offseason, the 2025 NFL season is finally here. While the Week 1 card features a couple of massive games — including an AFC Divisional Round rematch in Buffalo — the marquee game of the day for my money comes in the NFC North, where we’ll see the Detroit Lions take on the Green Bay Packers in what should be a spectacle at Lambeau Field. This is a pivotal early-season clash as it relates to NFC North divisional positioning down the road, plus potential playoff seeding implications. While the Lions were 15-2 a year ago, I’m all in on this Packers team in 2025 and that starts with this weekend.

The Packers were already a team that I was looking to back early and often this season, and that impulse only got stronger once Green Bay acquired Micah Parsons for an aging Kenny Clark and a pair of first-round picks. Parsons was questionable for this game initially, but he is expected to make his debut in Green and Yellow on Sunday, and that could be the deciding factor in this contest. The Packers are a team that desperately needs to generate more pressure on the opposing quarterback, and with Parsons now part of a revamped defensive front, Green Bay should be able to make life difficult for Jared Goff and force him to make a couple of costly mistakes in a hostile road environment.

However, the real edge for Green Bay in this matchup is on the other side of the ball, where the Packers’ solid offensive line is going up against a Detroit defensive line that will be without Levi Onwuzurike and Za’Darius Smith. Look for Green Bay to establish the run early and open up the play-action pass game for Jordan Love, who has all of the tools to finally put it together in his 3rd season as a starter in Matt LaFleur’s system. I’ll take Green Bay on the money line.

Lions vs Packers prediction: Packers ML (-130) available at time of publishing. Playable to -140.

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This is an instance where my handicap on the Packers winning this game also aligns nicely with the game going under the posted total. Green Bay’s pass defense would be the main area of concern here, but I’m confident that the Packers can get to the quarterback far more consistently than a season ago, particularly with the insertion of Parsons into the front seven. As for the Lions, Detroit struggled mightily at the end of last season, but the Lions were actually a fairly solid unit prior to the massive rash of injuries that hit the defense in November and December. With both teams expected to keep the ball on the ground in this one, the Under is my preferred pick in this market on Sunday.

Lions vs Packers pick: Under 47.5 (-110) available at time of publishing. Playable to 47.

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