Green Bay Packers

Green Bay Packers vs Arizona Cardinals Prediction, Odds and Picks for Tomorrow, 10/19/25

State Farm StadiumFOX
Packers
3-2-1
Packers
Tomorrow
Cardinals
2-4
Cardinals

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Arizona Cardinals
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Packers vs Cardinals Pickswise Expert Predictions

Green Bay Packers
Point Spread Pick
ARI Cardinals +7.0(-110)

One of the more fascinating games on the NFL Week 7 card comes in Phoenix, where the Packers are set to take on the Arizona Cardinals in a game between a pair of teams that are a bit closer than what recent results would indicate. The Packers appear to be a clear playoff team at the moment, with Green Bay sitting in first place in the NFC North and holding one of the best records in the NFC. On the other side, the Cardinals blew another lead in the 4th quarter against the Colts a week ago, a game in which the Colts intercepted Jacoby Brissett late in the 4th quarter to seal the victory. However, it was pretty encouraging to see Arizona hang tough in a difficult spot against one of the hottest teams in football a week ago, even without the services of its starting quarterback. And while Kyler Murray is currently listed as questionable for Sunday’s game, the market seems to be suggesting that Jacoby Brissett will get his second straight start in this one. 

I’m immediately drawn toward backing the Cardinals this week, especially since nobody is going to want to bet on Arizona following how this team has played over the last month. With that in mind, regardless of if Murray suits up or not on Sunday, this number is a bit disrespectful to a Cardinals team that did cover the number as a nearly 10-point underdog a week ago. The Cardinals are no stranger to keeping games close, with Jonathan Gannon’s team having lost a quartet of games by a combined 9 points over the past 4 weeks. Arizona has actually led in the 4th quarter of each contest, which also points me in the direction of the Cardinals catching a touchdown at home in this one. We can expect this game to be close — much like every game involving the Cardinals to this point in this season. Ultimately, Green Bay is getting a bit too much respect in the market for my liking here, especially since the Packers struggled to put away the Bengals at home last weekend. Let’s hold our noses and take Arizona to keep it close in this one. 

Packers vs Cardinals prediction: Cardinals +7 available at time of publishing. Playable at that number. 

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Arizona Cardinals
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Caleb Wilfinger

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
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