Houston Texans vs Los Angeles Chargers Prediction, Odds and Picks for Saturday, 12/27/25

The Houston Texans will be trying to extend their 7-game winning streak when they visit the Los Angeles Chargers in Week 17 of the NFL season on Saturday afternoon. It has been a well-deserved surge, too. The 7 games include victories over Jacksonville, Buffalo, Indianapolis and Kansas City — when the Chiefs were still in contention and had Patrick Mahomes on the field. Head coach Demeco Ryans’ team is simply rolling right now, fueled by arguably the best defense in football. As such, my Texans vs Chargers pick is for the visitors to cover.

Los Angeles is on a 4-game streak of its own, although it flirted with disaster against Philadelphia (22-19 in overtime) and Kansas City (16-13 after Mahomes tore his ACL). Aside from when it faced horrific defenses in Dallas and Las Vegas, this offense has been quite poor dating all the way back to Week 11 — a 35-6 setback against Jacksonville. It’s hard to see Justin Herbert and company having their way with this Houston defense. I wouldn’t be overly alarmed by the Texans’ 23-21 scare against Las Vegas last weekend. That was a classic lookahead spot against a horrible team with much bigger game against the Chargers on the immediate horizon. The real Houston squad should show up on Saturday.

Houston Texans vs Los Angeles Chargers prediction: Texans +2 (-110) available at time of publishing. Playable at that number.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our Texans vs Chargers predictions.