Indianapolis Colts vs Los Angeles Chargers Prediction, Odds and Picks for Sunday, 10/19/25

Indianapolis has topped the 29-point mark in 5 of 6 games this season, but also yielded at least 27 points 3 times. The Colts have faced 3 of the 10 worst defenses this season from a yardage standpoint (Titans, Dolphins, Cardinals), but put up 473 yards against Denver, which is 2nd in the NFL in yards allowed per game.

Los Angeles was riding a 4-game Under streak prior to cashing the Over in last Sunday’s 29-27 triumph at Miami on a 43 total. The teams combined for 34 2nd-half points after 1 touchdown was scored in the first half to go along with 5 field goals.

The Chargers scored a combined 28 points in losses to the Giants and Commanders before busting out for 29 points against the Dolphins. At home, Los Angeles has cashed the Under twice in 2 games after closing out last season on a 5-game Over streak at SoFi Stadium.

The Colts are 3-3 to the Over this season, as the 3 Overs have seen Indianapolis and its opponents combine for 57 points or more. In the 3 Unders, they have combined for 47 or fewer points.

Los Angeles and its opponents totaled 48 points or less in each of its first 5 games before the combined 56 points against Miami. The total sits at 48.5 across the board, which is the highest total for the Chargers this season. Against Washington, the total closed at 48 as the Chargers scored 10 points in the opening quarter and were outscored, 27-0, in the final 3 quarters.

The Chargers rank 7th in the NFL in yards allowed per game at 301.7 and 6th in passing yards allowed at 177.5. Jones is averaging 250 passing yards per game, while getting sacked only 5 times, the fewest of any starting QB in the league.

This game will likely see these teams combine to score in the low 20s and stay Under the total.

Colts vs Chargers pick: Under 48.5 (-110) available at time of publishing. Playable to 47.5.

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