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HomeNFLNFL PredictionsIndianapolis Colts vs Tennessee Titans Prediction, Odds and Picks

Indianapolis Colts

Indianapolis Colts vs Tennessee Titans Prediction, Odds and Picks for Sunday, 09/21/25

Updated: 5:00 AM ET Sep 22, 2025

Nissan StadiumCBS

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Colts

1:00 PM ETSun Sep 21

0-2

Titans

Tennessee Titans

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Kevin Rogers

Updated: 5:00 AM ET September 22, 2025

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Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.

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