Jacksonville Jaguars vs Cincinnati Bengals Prediction, Odds and Picks for Today, 09/14/25

Both the Jacksonville Jaguars and Cincinnati Bengals are 1-0 heading into a Week 2 showdown on Sunday in Cincinnati. However, the Bengals can hardly feel good about what they accomplished despite beating the AFC North rival Cleveland Browns last weekend. Joe Burrow and the offense struggled mightily throughout a 17-16 victory, as the former LSU standout completed just 14 of 23 passes for 113 yards with 1 touchdown and no interceptions. Ja’Marr Chase was held to an anemic 26 yards on 2 receptions. There was also no semblance of a running game; Cincinnati gained 46 yards from 23 rushing attempts as a team.

Yes, Cincinnati’s defense fared well — but keep in mind that it faced a Cleveland offense that is expected to be among the most inept units in the NFL. Whereas the Jaguars may not be anything special, they should be a lot more dangerous than the Browns. Like Burrow (2020), Trevor Lawrence is a former #1 overall pick (2021). This is a guy who has plenty of potential — especially when the ground attack is helping him like it did this past Sunday. Jacksonville rushed for 200 yards on 32 attempts during a 26-10 victory over the Carolina Panthers, with Travis Etienne Jr. racking up 143 yards. As for #2 overall pick Travis Hunter, he gained just 33 receiving yards, but he led his team with 6 catches. It goes without saying that Hunter will command plenty of attention from Cincinnati’s defense. I can’t give the Jags more than a field goal in this situation.

Jaguars vs Bengals prediction: Jaguars +3.5 (-110) available at time of publishing. Playable at that number.

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An even better Jaguars vs Bengals pick is Under 49.5. Shockingly, Cincinnati’s offense was utterly anemic in Week 1. It averaged a horrendous 2.9 yards per play. Simply nothing worked either on the ground or through the air. Fortunately for the Bengals, their defense stepped up. That’s not saying much given that the Browns were the opposition in question, but holding anyone to 16 points is good for a much-maligned Cincy defense that was awful in 2024. Thank goodness Trey Hendrickson ended his holdout and signed an extension. Both Hendrickson and BJ Hill had 1 sack and 1 tackle for loss apiece in the season opener.

Jacksonville can also feel good about its defense. The unit limited Carolina to 4.2 yards per play while inducing 3 turnovers (2 interceptions, 1 fumble) out of Bryce Young. On the other side of the ball, the Jaguars may be able to move the ball this weekend. If they do, though, their drives could be run-heavy slogs like they were against the Panthers. Even if points are put on the board, the clock should be moving. All things considered, 49.5 is too high of a number — at least until the Bengals’ offense gets on track, which probably won’t happen in Week 2.

Jaguars vs Bengals prediction: Under 49.5 (-115) available at time of publishing. Playable to 48.

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