Jacksonville Jaguars

Jacksonville Jaguars vs Indianapolis Colts Prediction, Odds and Picks for Today, 12/28/25

Lucas Oil StadiumCBS
Jaguars
11-4
Jaguars
Today
Colts
8-7
Colts
Indianapolis Colts
Google News

Jaguars vs Colts Guest Expert Predictions

Game Totals Pick
Under 48.5(-115)

Each of the last 6 matchups between these AFC South rivals have finished Over the total. The Jaguars routed the Colts 3 weeks ago, 36-19 on a 45 total, as this number has been pushed to 48.5 in the rematch. These squads have not played to a listed total this high since late in the 2020 season as the Colts won, 28-14, which would clearly go under this total. Jacksonville is riding a 3-game over streak and is on a 6-2 stretch to the over since the start of November during its scoring barrage, averaging 33 points.

The Colts’ defense was shredded on Monday against San Francisco, allowing 48 points after not giving up a touchdown the previous week in Seattle. Since cashing three consecutive overs to close out October, Indianapolis is 4-3 to the under in the past 7 games. The Colts have bounced back nicely after a poor defensive outing, yielding an average of 18.6 ppg following a game they gave up at least 27 points.

Indianapolis needs to slow down Trevor Lawrence to have any shot at a win, as the Colts are allowing 250.7 passing yards per game, which is 31st in the league. In the first matchup in Jacksonville, Lawrence threw for 244 yards and a pair of scores, while the Colts turned the ball over 3 times. Prior to scoring 27 points against the 49ers on Monday, Indianapolis didn’t bust the 20-point mark in any of the previous four games. During its 7-1 start, the Colts posted at least 29 points in all seven victories. The Colts’ offense is not as explosive with Rivers in there, but the defense has shown a tendency to rebound after a bad showing.

Under 48.5 available at time of publishing. Playable to 48.

Jaguars vs Colts Pickswise Expert Predictions

Point Spread PickBest Bet
IND Colts +6.5(-110)

Jacksonville has made an impressive jump in its first season with Liam Coen as head coach, clinching its first playoff berth since 2022. The Jaguars extended their winning streak to 6 games after an impressive 34-20 victory at Denver last Sunday as 3.5-point underdogs. During this hot stretch, the Jags have scored at least 34 points 4 times and have topped the 25-point mark all six games. In fact, Jacksonville has posted more than 25 points in eight consecutive games after getting held to 19 points in a pair of October losses to the Rams and Seahawks. In the last 2 weeks, QB Trevor Lawrence has tossed 8 touchdown passes and is riding a 6-game streak with multiple TD passes.

The Colts (8-7) have seen their dreams of a division title, much less a playoff spot crumble over the last two months. Indianapolis leapt out to an incredible 7-1 record in Daniel Jones’ first season as starting QB of the Colts. However, the Colts have lost six of the past seven games and lost Jones for the season with a broken fibula suffered in a 36-19 defeat at Jacksonville in Week 14. Indianapolis turned to 44-year old Philip Rivers to try and save its season, but the Colts have lost in his first two starts to the Seahawks and 49ers.

Rivers helped the Colts cover as 13-point road underdogs in an 18-16 defeat two weeks ago, but he threw for 120 yards. He looked better in Monday’s 48-27 blowout loss to San Francisco, posting 277 passing yards and 2 touchdowns, but the Colts’ defense had its worst performance of the season in their second home setback. This has been a series dominated by the home team, as the Colts are 4-1 in the past five against the Jaguars at Lucas Oil Stadium. Jacksonville is the team to beat in the AFC South, but Indianapolis should give them a run here looking for revenge for the loss a few weeks ago.

Jaguars vs Colts prediction: Colts +6.5 available at time of publishing. Playable to +6

If you’re looking for a new sportsbook, check out Bet365, the world’s #1 sportsbook. They have an amazing sign-up offer where you can INSTANTLY receive $150 in bonus bets from a $5 wager, regardless of whether that bet wins or loses! There’s no catch, it’s really that simple. ⏰ in time to fade or follow our experts’ Jaguars vs Colts predictions.

Photo of Caleb Wilfinger

Caleb Wilfinger

Deputy Editor for Pickswise with years of experience handicapping and giving out winning picks. Lover of all US sports and Southampton FC. For Caleb Wilfinger media enquiries, please email contact@pickswise.com.
Read more about Caleb Wilfinger