Jacksonville Jaguars vs Indianapolis Colts Prediction, Odds and Picks for Today, 12/28/25

Jacksonville has made an impressive jump in its first season with Liam Coen as head coach, clinching its first playoff berth since 2022. The Jaguars extended their winning streak to 6 games after an impressive 34-20 victory at Denver last Sunday as 3.5-point underdogs. During this hot stretch, the Jags have scored at least 34 points 4 times and have topped the 25-point mark all six games. In fact, Jacksonville has posted more than 25 points in eight consecutive games after getting held to 19 points in a pair of October losses to the Rams and Seahawks. In the last 2 weeks, QB Trevor Lawrence has tossed 8 touchdown passes and is riding a 6-game streak with multiple TD passes.

The Colts (8-7) have seen their dreams of a division title, much less a playoff spot crumble over the last two months. Indianapolis leapt out to an incredible 7-1 record in Daniel Jones’ first season as starting QB of the Colts. However, the Colts have lost six of the past seven games and lost Jones for the season with a broken fibula suffered in a 36-19 defeat at Jacksonville in Week 14. Indianapolis turned to 44-year old Philip Rivers to try and save its season, but the Colts have lost in his first two starts to the Seahawks and 49ers.

Rivers helped the Colts cover as 13-point road underdogs in an 18-16 defeat two weeks ago, but he threw for 120 yards. He looked better in Monday’s 48-27 blowout loss to San Francisco, posting 277 passing yards and 2 touchdowns, but the Colts’ defense had its worst performance of the season in their second home setback. This has been a series dominated by the home team, as the Colts are 4-1 in the past five against the Jaguars at Lucas Oil Stadium. Jacksonville is the team to beat in the AFC South, but Indianapolis should give them a run here looking for revenge for the loss a few weeks ago.

Jaguars vs Colts prediction: Colts +6.5 available at time of publishing. Playable to +6

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