Kansas City Chiefs vs New York Giants Prediction, Odds and SNF Picks for Sunday, 09/21/25

Two 0-2 teams clash on Sunday Night Football, and while one was expected to be in this position, the other has never been winless at this juncture. In fact, at no point during the Andy Reid and Patrick Mahomes era have the Chiefs started 0-2, until now. 

After Week 2, oddsmakers and NFL critics are feeling better about the New York Giants. While no one expects a Super Bowl this season, they put up 37 points on the Cowboys in Dallas last week, finally showing signs of life on an offense that’s been dead for a decade. Russell Wilson looked like the 2013 Super Bowl version of himself, hoisting up one long ball after another and connecting with Malik Nabers frequently. The dynamic 2nd-year wideout tallied 167 receiving yards and 2 touchdowns. The Giants’ defense wasn’t quite as stingy, but they were hitting hard and their front 7 made life difficult for Dak Prescott all game.

Normally, even with New York showing signs of improvement, this would be an automatic wager on the Chiefs. After all, the legendary tandem of Andy Reid and Patrick Mahomes have repeated Super Bowl visits in 5 of the last 6 seasons, so they know a thing or 2 about rising to the occasion. But last week was another indication of how difficult life currently is for Kansas City, particularly on offense. Against the Eagles, Kansas City’s offense looked good in moments, but they also made mistakes in the worst spots. A turnover at the goal line that would have meant the go-ahead score, and their inability to convert on 3rd downs (they were just 4-12) ended up being the story of the game.

The Giants’ defense is good enough to cause turmoil for an offensive line that has not protected Mahomes well enough (4 sacks, 18 QB hits in the first 2 weeks), and the Giants’ offense has enough momentum to re-create some magic and hang with last season’s AFC champions. We expect another close game, as nothing seems to be coming easy this year for the Mahomes and company.

Chiefs vs Giants prediction: Giants +6 (-105) available at time of publishing. Playable at that number.

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