Los Angeles Chargers vs New York Giants Prediction, Odds and Picks for Sunday, 09/28/25

The Jaxson Dart era will be getting underway for the New York Giants when they entertain the Los Angeles Chargers in Week 4 of the NFL season on Sunday afternoon. Dart showed signs of promise during the preseason, but the real things is an entirely different scenario — especially against an undefeated Los Angeles outfit that boasts one of the best defenses in the league. As such, my Chargers vs Giants pick is for the visitors to win and cover. Although Dart has potential, head coach Brian Daboll’s decision has more to do with Russell Wilson than it does with the rookie. Wilson had one good game against a porous Dallas defense, but the veteran was otherwise a shadow of his former self. In the short time, I don’t have any more faith in Dart than I did in Wilson.

As for the Chargers, they find themselves as the opposite end of the spectrum from the 0-3 Giants. Los Angeles is quite simply looking like a well-oiled machine under second-year head coach Jim Harbaugh. The Bolts are #9 in passing defense and #2 in yards per pass attempt allowed. They are also #9 against the run and #4 in scoring defense. Their offense shouldn’t have to do too much in order to prevail by at least a touchdown. The norm from Justin Herbert and company is between 20 and 27 points, which would likely be enough to handle the G-Men.

Los Angeles Chargers vs New York Giants prediction: Chargers -6 (-110) available at time of publishing. Playable to -7.

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The Giants scored 37 points in an overtime loss to the Cowboys; they put up a grand total of 15 points in their other 2 losses. New York could have waited until Week 5 against the lowly Saints to send Dart out there, but desperate times call for desperate measures and Daboll decided to pull the trigger now. Instead of making his first start against the worst team in all of football, Dart has to go up against arguably the best defense in the business. Good luck with that! It’s the main reason why my Chargers vs Giants pick is Under 43.5.

Meanwhile, L.A.’s offense has been solid but unspectacular. Herbert is playing mistake-free football for the most part, but he really hasn’t set the world on fire in 2025 — or at any point in his career. Najee Harris is on injured reserve, so the backfield now belongs entirely to rookie Omarion Hampton. Moreover, the offensive line is banged up. Rashawn Slater is out for the season; both Mekhi Becton and Bradley Bozeman are questionable for Sunday. All things considered, this has the makings of a relatively low-scoring affair.

Los Angeles Chargers vs New York Giants prediction: Under 43.5 (-105) available at time of publishing. Playable at that number.

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