Los Angeles Rams vs Philadelphia Eagles Prediction, Odds and Picks for Sunday, 09/21/25

One of the biggest games on the NFL Week 3 card features a rematch of last season’s NFC Divisional Round matchup between the Los Angeles Rams and Philadelphia Eagles at Lincoln Financial Field. That game was played right down to the wire, and last year’s Eagles team during that playoff run was a significantly better unit than what we’re currently seeing. In fact, Philadelphia was fortunate to win each of its first 2 games this season, as the Eagles were aided buy a number of drops from CeeDee Lamb down the stretch in Week 1, before getting an absolute gift of an interception courtesy of Travis Kelce to flip the game on its head and give Philadelphia the inside track to a victory.

A lot of my concerns with the Eagles heading into the season have come to fruition, as the defense has taken a noticeable step back and the offense has been a total slog under new offensive coordinator Kevin Patullo. Jalen Hurts has thrown for just 253 yards to this point, and I also have some serious reservations about Saquon Barkley’s production, given that he’s averaging a very middling 3.7 yards per rush. At some point, this offense is going to have to do something worth talking about, and I don’t see that being the case against a Rams defense that has quietly been one of the best units in the sport through the first 2 weeks of the campaign. In fact, Los Angeles boasts an extremely stout defensive front, one that has the ability to give the Eagles offensive line plenty of issues on Sunday.

On the other side of the ball, the Rams passing offense is starting to really click following a middling start against an excellent Texans defense in Week 1. Matthew Stafford is still one of the sharpest minds at the quarterback position in the sport and the wide receiver tandem of Devante Adams and Puka Nacua appear to be a very successful pairing in Sean McVay’s offense. Speaking of McVay, he excels in these spots (18-11-2 ATS as an underdog of more than a field goal) and I’ve got full confidence in the Rams’ ability to keep this one close and potentially even win the game outright.

Rams vs Eagles prediction: Rams +3.5 available at time of publishing. Playable at that number. 

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Regardless of which team ends up winning this game, my only play on the total is on the under here. At the end of the day, until the Eagles prove that they can consistently and effectively call plays that are tendency breakers on early downs, I simply can’t believe in this offense to put up big numbers, especially against a defense of this caliber. Philadelphia is averaging just over 4 yards per play on the season and there is certainly reason for concern for the Eagles as it relates to the consistency of their offense going forward. While the Rams appear to have the better offense in this game, there is still something to be said for McVay’s offense playing at a more deliberate pace and running the ball more often than not on early downs. This projects to be a game that is played in the low-20s, so I’ll back the under at the current price.

Under 44.5 available at time of publishing. Playable at that number.