Los Angeles Rams vs Tennessee Titans Prediction, Odds and Picks for Sunday, 09/14/25

The Los Angeles Rams could be in good shape to start the season 2-0 when they visit the Tennessee Titans in Week 2 on Sunday afternoon. Los Angeles opened with a 14-9 home win over the Houston Texans last weekend. It was not a spectacular performance by any means, but keep in mind that the Rams probably won’t have to be spectacular to beat Tennessee–widely expected to be one of the worst teams in the league going into this year. My Rams vs Titans prediction is for the visitors to win and cover. That is in part due to quarterback Matthew Stafford, whose back injury appears to be a thing of the past. Stafford completed 21 of 29 attempts for 245 yards with a touchdown and no interceptions against Houston.

Tennessee put up a decent fight while losing at the Denver Broncos 20-12 this past Sunday. However, there was not much to like about the offense. Cam Ward, the #1 overall pick this spring, went 12-of-28 for 112 with no touchdowns, no interceptions, no rushing attempts and 1 fumble lost. Ward obviously has plenty of future potential, but there will likely be some growing pains in 2025. It’s hard to see the Titans suddenly coming a well-oiled machine in Week 2. It doesn’t help that Ward and company have to face a Rams defense–led by Jared Verse at outside linebacker–that had no trouble containing Houston’s C.J. Stroud in the season opener.

Los Angeles Rams vs Tennessee Titans prediction: Rams -5.5 (-110) available at time of publishing. Playable at that number.

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Unsurprisingly, Titans vs Broncos in Week 1 featured nothing less than shambolic offense. Tennessee gained a mere 2.4 yards per play. It wasn’t only Ward’s fault — far from it, in fact. The visitors churned out just 71 rushing yards in Denver while averaging 3.4 yards per attempt. Fortunately for the Titans, their defense played well. They limited Denver to 4.5 yards per play, which is terrible in itself but only looks decent when you compare it to Tennessee’s ineptitude. I actually don’t have much faith in either offense on Sunday, so my Rams vs Titans pick is Under 42.5.

Even if he is entirely 100 percent, Stafford is 37 years and can’t do it all alone with Puka Nacua (10 catches, 130 yards in Week 1). The Rams got only 72 rushing yards on 25 carries (2.9 average) against Houston. That is simply not going to work long-term for this offensive attack. It should also be noted that offensive linemen Steve Avila and Kevin Dotson both sustained ankle injuries in the opener and are currently listed as questionable.

Los Angeles Rams vs Tennessee Titans prediction: Under 42.5 -5.5 (-115) available at time of publishing. Playable to 42.

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