Minnesota Vikings

Minnesota Vikings vs Los Angeles Chargers Prediction, Odds and TNF Picks for Today, 10/23/25

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Vikings vs Chargers Guest Expert Predictions

Point Spread Pick
MIN Vikings +3.5(-120)

Thursday night games are always tough to predict. In general, there are more outlier results than most contests. Take, for example, the last 3 weeks, when the 49ers, Giants, and Bengals all won outright as considerable underdogs. This game provides an even tougher challenge to handicap, since the Chargers and Vikings are wholly unfamiliar opponents that only face each other once every 4 years. Adding to the puzzle is the fact that both outfits enter Week 8 following losses at home.

From a coaching perspective, this is a very evenly-matched battle. Jim Harbaugh’s prowess as a football coach is common knowledge at this point, a former quarterback who’s as good as any head-man at cultivating his franchise leader, and Harbaugh’s teams are usually known for their playing tough, hard-hitting style. Kevin O’Connell is right there with his elder, one of the NFL’s best young minds who produced multiple playoff rosters with multiple quarterbacks in just 4 years at the helm. 

The most significant difference between the Chargers and Vikings is health. LAC is undergoing a crisis, with important players like left tackle Joe Alt and linebacker Khalil Mack now missing multiple games. Their running back room has also been decimated. Najee Harris was out before the season began and their promising rookie, Omarion Hampton, is on the injured reserve. In Week 7, they only ran for 54 yards against the Colts, forcing Justin Herbert to throw 55 times in what ended up being a blowout loss. 

Minnesota has their share of injuries too (linebacker Andrew Van Ginkel, running back Aaron Jones, center Ryan Kelly) but they’re in a better overall position. The Vikings’ depth has proved formidable. Carson Wentz will make his 4th start of the season on Thursday and he’s mostly played well, and O’Connell’s roster still has game-changing star power on both sides of their roster. We can’t support the direction of the home team here.

Vikings vs Chargers prediction: Minnesota Vikings +3 (-110) available at time of publishing. Playable at that number.

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Chris R. Farley
Game Totals Pick
Over 44.5(-110)

Predicting the total may be even more difficult between 2 unfamiliar teams, but the Chargers and Vikings both have similar patterns of performance. Most weeks, each offense finds itself scoring 20 or more points. The Chargers have eclipsed the 20-point mark in 5 out of 7 games, whereas the Vikings have done so in 5 out of 6. Both rosters came into the season known for their defensive prowess, but injuries have held each unit back.

So far, Minnesota would qualify as the better resistance, permitting just 20.8 points and 301.7 yards per game, both top-10 marks. But the Chargers aren’t far behind, permitting 23.3 points (17th) and just 315.9 yards per game (13th). Neither defense limits opposing run games as well, particularly the Chargers. The Vikings are 15th in opponent yards per carry (4.2) but the Chargers are a pitiful 28th, allowing 5.1 yards on each run. 

We like that for both offenses on Thursday. In each case, neither Justin Herbert nor Carson Wentz can depend on their rushing attacks on a weekly basis, both ranked in the bottom half of the NFL in rush yards per game. This matchup presents a plus-opportunity for both ground games, while Wentz and Herbert will both want to avenge performances from last Sunday where they threw multiple interceptions in a loss.  This number sits in “no man’s land,” between key numbers for low-scoring and high-scoring projections, but we like the offenses to eventually thrive.

Vikings vs Chargers pick: Over 44.5 (-110) available at time of publishing. Playable to 45.

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Chris R. Farley
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Chris Farley

Chris is a writer for Pickswise who’s been handicapping the NFL since 2011. He began his public betting career as a betting writer, and has since become a contributing analyst for various betting sites and shows. He was a 5th place winner ($114k) in the 2021 NFL Circa Millions contest, and he owns his own sports betting podcast, Laying the Points. Chris approaches handicapping using psychosocial principles and nuanced market analysis. The NFL and NBA are his favorite and most profitable sports.
Read more about Chris Farley

Related game props

Minnesota Vikings
Money Line & Player Receptions Pick
LA Chargers Win & K. Allen (LAC) 5+ recs(+148)

The Vikings are blitzing at the 2nd-highest rate in the NFL through 7 weeks (38.9%) while also leaving the middle of the field open at a 63.9% rate, according to Sharpes Football Analysis. This immediately brings my attention to Keenan Allen, who’s had 5+ receptions in 6 of 7 games this season and has seen 26 of his 65 targets in the short center of the field. Herbert will have to get the ball out quickly to beat the blitz, and that’s where Allen should be a safety valve compared to Quentin Johnson and Ladd McConkey, who are running more deep and intermediate routes this season. Last week, we saw DeVonta Smith lead the Eagles with 4 targets on short routes against this Vikings defense.

Regarding the ML addition of the Chargers, I see them as the more desperate team and home teams are 5-2 SU this season on Thursday Night Football. The Vikings’ wins over their last 4 games aren’t too impressive when you consider that they were against the Jake Browning-led Bengals and Miami Dolphins. This is a get-right game for the Chargers and Joe Alt returning at left tackle puts them over the edge.

Los Angeles Chargers
Minnesota Vikings
Anytime Touchdown Scorer Pick
Q. Johnston (LAC) to score a TD(+155)

Regardless of how the Chargers offense approaches this contest, they’ll need to have some success through the air. On that front, it’s hard to ignore the value we’re getting with Quentin Johnston to find the end zone at the current odds. After all, the TCU product is in the midst of a breakout season in 2025, and he’s finally been able to establish a good rapport with Justin Herbert over the first 6 games.

Johnston has hauled in 14 receptions and a pair of touchdowns over the past 3 weeks, which gives us confidence in his ability to haul in a few red-zone targets on TNF, especially since Herbert should be looking to get the ball out quickly against a blitz-happy Vikings defense. Let’s take Johnston to find paydirt for the 6th time this season.

Los Angeles Chargers
Minnesota Vikings
Anytime Touchdown Scorer Pick
J. Addison (MIN) to score a TD(+220)

On the Minnesota side of things, the passing game has been a bit up-and-down to this point, which isn’t a surprise given that the Vikings quarterback situation has been in flux this season. This week, Carson Wentz will remain under center for Kevin O’Connell’s offense, and that gives the Vikings a decently high floor in a game that could be deceptively higher scoring.

With that in mind, it’s nice to have Jordan Addison as a security blanket for Wentz and this Minnesota passing offense. In the 3 weeks since Addison returned from a suspension, he has 18 receptions for nearly 300 yards and a touchdown, which bodes well for his target share this week. Let’s roll with the Vikings’ #2 wideout to find the end zone once again on Thursday Night Football.

Los Angeles Chargers

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