New England Patriots vs Tennessee Titans Prediction, Odds and Picks for Sunday, 10/19/25

The New England Patriots surprisingly find themselves atop the AFC East heading into Week 7 of the NFL season. They are 4-2 and own the head-to-head tiebreaker over the Bills, having taken down Josh Allen and company in Buffalo earlier this month. New England now faces arguably the worst team in football, the Tennessee Titans, on Sunday afternoon. This is a tale of 2 franchises going in opposite directions — and with the spread set at no more than a touchdown, my Patriots vs Titans pick is for the visitors to win and cover. Tennessee just fired head coach Bill Callahan — and for good reason. The Titans 1-5 and their only win is a miracle (“fluke” would probably be an even more accurate description) fourth-quarter comeback from 15 points down against the Cardinals, made possible by Arizona RB Emari Demarcado dropping the ball before going into the endzone followed by one of the luckiest touchdowns in football history after Arizona fumbled an interception. 

Teams can sometimes galvanize around an interim head coach, but that’s usually when they have a chance to really turn around the season. That obviously isn’t the case with Tennessee. The Titans know as well as everyone else that this is a rebuilding process that will require multiple years. Now they are being asked to compete with a team is on a 3-game winning streak and has lost just once since Week 1 in a 1-possession game against the 4-1 Steelers? Drake Maye looks like the real deal at quarterback and New England is 3-0 on the road. It’s not like the Titans have any kind of significant home-field advantage, either, so the Patriots should be even bigger favorites and can be expected to win by more than a touchdown. 

New England Patriots vs Tennessee Titans prediction: Patriots -7 (-110) available at time of publishing. Playable at that number.

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The Titans do not inspire any confidence on the offensive side of the ball. Cam Ward was the #1 overall pick in 2025 and obviously has some talent, but this is a terrible situation for the Miami product. His offensive line is awful and he also isn’t getting any help from skill-position players. Ward has thrown more interceptions (4) than touchdowns (3) and has already been sacked a ridiculous 25 times. As a team, Tennessee is averaging an anemic 3.9 yards per rushing attempt.

Maye has been slinging it around nicely so far this season, but New England is still a team that wants to win by playing fundamental football — dominating on defense and running the football. That should certainly be the game script for Sunday. The Patriots will likely jump out to a quick lead and can then work the clock with running backs Rhamondre Stevenson and TreVeyon Henderson. New England is outside the top 15 in total offense and outside the top 10 in scoring offense, so — even though it is playing well overall — it’s not setting the world on fire.

New England Patriots vs Tennessee Titans prediction: Under 42.5 (-115) available at time of publishing. Playable to 42.

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