New York Giants vs Denver Broncos Prediction, Odds and Picks for Sunday, 10/19/25

The New York Giants will be looking to build on a huge win over the Philadelphia Eagles when they visit the Denver Broncos on Sunday afternoon. New York has won 2 of its last 3 games after upsetting Philadelphia 34-17 last Thursday night. This stretch also includes a 21-18 victory over the Chargers. A bad loss at New Orleans came in between those 2 impressive results, but that should never have happened. The Giants turned the ball over 5 times and did not force any turnovers, so that was the only reason why they lost to the lowly Saints. The bottom line is that this team simply looks different now that rookie quarterback Jaxson Dart is under center instead of Russell Wilson. As such, my Giants vs Broncos pick is for the visitors to cover a touchdown spread.

This is a good spot for New York in which to be competitive. Not only does head coach Brian Daboll’s squad have a ton of momentum right now, but it is also playing on a long week after it featured on Thursday Night Football against Philadelphia. It’s basically a mini-bye of sorts. The Broncos, on the other hand, have much less rest after traveling home from their Week 6 London game. It wasn’t a good performance across the pond, either. They just barely scraped past the Jets 13-11, and the Jets might be the worst team in football — yes, arguably even worse than the Titans. Bo Nix has been unspectacular so far in year 2, so I don’t think Denver will score enough points to cover. It might win thanks to its defense, but asking the home side to prevail by at least a touchdown is probably too much.

New York Giants vs Denver Broncos prediction: Giants +7 (-110) available at time of publishing. Playable at that number.

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Fortunately for the Broncos, there are plenty of good things to say about their defense. It is a unit that ranks second overall in the NFL, second in scoring defense, fourth against the pass, third in yards per pass attempt allowed, sixth against the run and ninth in yards per rushing attempt allowed. It also leads the league in sacks by a country mile with 30 (no other team has more than 20). Cornerback Pat Surtain II may be the best at his position in the NFL. Giants wide receiver Malik Nabers is out for the season with a torn ACL, which is especially bad news given the strength of Denver’s secondary. As well as Dart is playing, this is very difficult spot for him. As such, my Giants vs Broncos pick is Under 40.5.

The Giants’ defense has improved dramatically since surrendering 40 points to the Cowboys in Week 2. No other opponent other than New Orleans has scored more than 22, and the Saints’ 26-point effort included an interception return for a touchdown. Much of the Saints’ offense came on a single play, an 87-yard TD pass. They otherwise had a lot of short fields due to the Giants’ turnovers. The strength of the Broncos’ offense has been the run — so even they sustain some scoring drives, they will likely be methodical and clock-sapping. Anything in the 40s is too high of a number for me.

New York Giants vs Denver Broncos prediction: Under 40.5 (-118) available at time of publishing. Playable at that number.

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