New York Giants vs New Orleans Saints Prediction, Odds and Picks for Sunday, 10/05/25

The New York Giants finally broke through the win column in Week 4, sending the Los Angeles Chargers to their first loss, 21-18, at MetLife Stadium. Rookie QB Jaxson Dart led the way in his first NFL start, throwing a TD pass and running for another score, although he sustained a hamstring injury. It wasn’t all great news for the Giants, who lost top wide receiver Malik Nabers for the season with a torn ACL. New York travels to New Orleans to face the 0-4 Saints, who almost pulled off the biggest upset of the season.

Following a 31-point beatdown in Seattle, the Saints trailed the Bills 21-19 with less than 8 minutes remaining in regulation. Buffalo scored the final 10 points to beat New Orleans, 31-19, although the Saints grabbed the cover as 14.5-point road underdogs. The Saints, who used to be nearly unbeatable at Caesars Superdome, have lost their last 5 home contests, including the first 2 this season to Arizona and San Francisco. Saints’ QB Spencer Rattler is still seeking his first victory as an NFL starter, but has shown some upside of late. Rattler has been intercepted once this season, while throwing 5 TDs in the last 3 games. He has not eclipsed 218 passing yards in a game as he faces a Giants’ pass defense that ranks 25th in yards allowed through the air.

The Saints held off the Giants last season at MetLife, winning 14-11 as 5.5-point road favorites. Both starting QBs for that game are no longer on these rosters, as Derek Carr outdueled Drew Lock in that low-scoring affair. Considering Dart is not 100% and the G-Men must now continue without their star wideout, we should see the first victory of the season for the Saints on Sunday.

Giants vs Saints prediction: Saints -2 (-110) available at time of publishing. Playable to 2.5.

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