New York Giants vs Philadelphia Eagles Prediction, Odds and Picks for Sunday, 10/26/25

We have a fascinating matchup in the NFC East on Sunday, one that pits the Giants and Eagles against each other just a few weeks after New York rolled over Philadelphia in a prime time spot at home on a short week. In that game, the Giants appeared to dominate the proceedings against a banged-up Eagles team in what was a 17-point victory. However, New York only outgained Philadelphia by 37 yards and was -0.6 in the yards per play differential. The Eagles also had 2 turnovers in the second half, which was a major part of why Nick Sirianni’s team failed to score a single point in the final 30 minutes of the contest. However, things have changed a bit since then, and this is a pretty solid situational spot to back the defending Super Bowl champions, who will surely be seeking revenge against a wounded Giants team.

New York was cruising against the Broncos a week ago, before the Giants just collapsed down the stretch, allowing a whopping 33 points in the 4th quarter en route to a 1-point loss at the buzzer in Denver. Given that the Giants are a pretty young team on both sides of the ball, this certainly feels like a loss that could turn into 2 losses for a New York side that is rapidly slipping out of the NFC playoff picture. On the other side, the Eagles passing offense is coming off its best performance of the season by a mile a week ago, and Jalen Hurts and company should see more success against a middling Giants defense. This feels like a smash spot for Philadelphia at home with revenge fresh in its mind from a few weeks prior. Back the Eagles in this one.

Giants vs Eagles prediction: Eagles -7 available at time of publishing. Playable at that number. 

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our Giants vs Eagles predictions.

Even with this being a repeated matchup from a few weeks prior, I show some value in the over given what we saw from these teams in the first game. After all, the Giants put up 34 points against an Eagles defense that has shown some vulnerabilities through the first 7 weeks. Jaxson Dart has shown an ability to have more success in the passing game that I previously thought he would, and we know that he should have cart blanche to take shots downfield, especially in a negative game script. On the other side, the Giants defense is 26th in EPA per play and 21st in success rate allowed, so I’m expecting Philadelphia to put up at least 27 points in this one.

Over 43.5 available at time of publishing. Playable to 44.