Philadelphia Eagles vs Buffalo Bills Prediction, Odds and Picks for Sunday, 12/28/25

The Philadelphia Eagles (10-5) are the only team to clinch a division title so far, wrapping up the NFC East after a 29-18 triumph at Washington last Saturday. The defending champions have rebounded nicely from a 3-game slide to win their last two games by double-digits, although they faced the Commanders and Raiders, who are not going to the playoffs. Philadelphia travels to Buffalo on Sunday seeking its 6th road victory of the season as the Eagles are listed as an underdog for the first time since last season’s Super Bowl.

The Bills (11-4) may not win their 6th straight AFC East crown, but Buffalo has shown it will be dangerous in the postseason. Buffalo is back home after rallying to shock New England two weeks ago and holding off Cleveland last Sunday to extend its winning streak to 4 games. The Bills were in a prime position to cover as 10.5-point road favorites last week against the Browns, leading 23-10 in the third quarter before Cleveland scored the final 10 points. Since Week 6, the Bills have not gone consecutive weeks without covering the spread, posting a 4-0 ATS mark in this situation.

The Eagles allowed the Giants to score 34 points in a Week 6 loss, but Philadelphia has not given up more than 24 points in nine consecutive games. The Bills have yielded at least 30 points in 4 of the past 6 games, including 32 points to the Buccaneers and 34 points to the Bengals. Buffalo has won in each of its 2 opportunities as a favorite of 3 points or less, but this is a short number against a Philadelphia team that has already clinched a division title.

Eagles vs Bills prediction: Eagles +1 available at time of publishing. Playable to Eagles ML (-110)

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