Philadelphia Eagles vs Kansas City Chiefs Prediction, Odds and Picks for Today, 09/14/25

The much-anticipated Super Bowl rematch is already here in Week 2 at Arrowhead Stadium in Kansas City. The Eagles routed the Chiefs 40-22 in February, as Philadelphia jumped out to a 34-0 lead on its way to its 2nd Super Bowl title in franchise history. The Chiefs return home after dropping the season opener in Brazil to the Chargers, 27-21 as 3-point favorites. QB Patrick Mahomes threw for 258 yards and a touchdown, while also running for a score in the loss. Philadelphia held off Dallas, 24-20 in the opening game of the NFL season. The Eagles failed to cover as 8-point home favorites, as QB Jalen Hurts rushed for a pair of touchdowns.

In the Super Bowl blowout, Hurts torched the Chiefs for 2 touchdown passes and a score on the ground. Mahomes posted 3 touchdown tosses, with 2 coming when Kansas City trailed by 34 points. Philadelphia is in the midst of a 16-1 run the past 17 games, with the lone loss coming against Washington when Hurts got injured early on last December. The Chiefs won all 10 home games last season, capped off by playoff victories over the Texans and Bills. The last time Kansas City lost at Arrowhead came in Week 16 of the 2024 season against Las Vegas in a 20-14 defeat.

This line has flipped as the Eagles are currently a short road favorite. Kansas City has not been a home underdog since the AFC title game in 2022 against Cincinnati, as the Chiefs held off the Bengals, 23-20, as 2-point ‘dogs. In Philadelphia’s last visit to Kansas City in 2023, the Eagles erased a 17-7 deficit to shock the Chiefs, 21-17 in a Monday-night Super Bowl rematch. Philadelphia outscored Kansas City, 14-0 in the 2nd half behind a pair of Hurts rushing touchdowns. It’s hard to forget about that rout in New Orleans in February by the Eagles, but the Chiefs have never started 0-2 with Mahomes as the starter and I like them as a dog.

Eagles vs Chiefs prediction: Chiefs +1 (-110) available at time of publishing. Playable to pick’em.

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The total for Super Bowl LIX closed at 48.5 as Philadelphia almost reached that number by themselves with 40 points on its own. The Eagles rolled the Chiefs, 40-22, although Over bettors needed points late in the game. Kansas City scored a touchdown with 2:54 to make it a 40-14 game, but it was obviously too little, too late for the defending champions.

The Eagles were set to cash the Over in Week 1 against the Cowboys as Philadelphia led at halftime 21-20 on a 47.5 total. The 2 NFC East rivals combined for 3 points in the 2nd half following a long weather delay as the game remained Under 47.5, much to the chagrin of Over bettors. The Chiefs played a pair of low-scoring games against the Chargers last season, but the AFC West foes hit the Over in the opener in Brazil last Friday. Los Angeles held off Kansas City 27-21 as the Over of 46.5 barely hit thanks to a late Harrison Butker field goal.

Last season, Kansas City was 5-5 to the Over at home, but the Over cashed in all 3 games with a total of 45 or more. There weren’t any convincing numbers in Philadelphia’s road games in 2024 from a total perspective. The Eagles hit the Over 4 times and Under 4 times away from Lincoln Financial Field. Philadelphia posted a 3-2 Over mark in its 5 opportunities as a road favorite, as the Eagles are playing their first road game since Week 16 at Washington last season.

The Eagles likely won’t put up 40 points against the Chiefs again, as this game will probably be more of a grind-it-out contest. Also, Jalen Carter didn’t get suspended for Philadelphia after his ejection for spitting on Dak Prescott in the opener, which will help out the Eagles’ defense.

Eagles vs Chiefs pick: Under 47 (-110) available at time of publishing. Playable to 45.5.

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