Philadelphia Eagles vs Tampa Bay Buccaneers Prediction, Odds and Picks for Sunday, 09/28/25

The defending Super Bowl champion Eagles pulled off a massive comeback last Sunday, erasing a 26-7 deficit to stun the Rams, 33-26, to improve to 3-0. Philadelphia travels to Tampa on Sunday to face the 3-0 Buccaneers, who needed a last-second field goal to fend off the Jets, 29-27. It marked the 3rd straight week that Tampa Bay took the lead after trailing in the final minute of regulation. The Bucs will be without Pro Bowl wide receiver Mike Evans, who is sidelined for nearly a month with a hamstring injury. Tampa Bay led New York 23-6 heading into the 4th quarter before the Jets outscored the Bucs 21-3 to take a 27-26 lead on a blocked field goal returned for a touchdown.

The Eagles were also involved in a late blocked field goal, denying the Rams the road victory, along with grabbing a miracle cover as 3.5-point favorites after returning that block for a touchdown as time expired. Looking ahead to Sunday, the Eagles try to avenge a pair of losses at Raymond James Stadium over the last two seasons. The first loss came in the Wild Card round to close out the 2023 season, an ugly 32-9 setback as 3-point favorites.

Tampa Bay punked Philadelphia again last September in a 33-16 beatdown, outgaining the Eagles 445-227 in the yardage department. The Eagles played without their top two receivers as AJ Brown and DeVonta Smith were both injured. Since that wake-up call, the Eagles have won 19 of their last 20 games and the only loss came when QB Jalen Hurts got knocked out in the first quarter of a last-minute defeat to the Commanders last December. Philadelphia is 14-6 against the spread in this span. The Bucs finished 0-3 last season in the games Evans missed due to a hamstring injury. Tampa Bay is 13-4 in its past 17 regular-season games with their top wideout in the lineup since the beginning of the 2024 campaign. Philadelphia should have plenty of motivation for the last 2 visits to Tampa and getting boat-raced by the Bucs.

Eagles vs Buccaneers prediction: Eagles -3.5 (-110) available at time of publishing. Playable to 4.

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