San Francisco 49ers

San Francisco 49ers vs Houston Texans Prediction, Odds and Picks for Sunday, 10/26/25

NRG StadiumFOX
49ers
5-2
49ers
Sun Oct 26
Texans
2-4
Texans
Houston Texans
Google News

49ers vs Texans Guest Expert Predictions

Point Spread Pick
HOU Texans -1.5(-110)

San Francisco (5-2) has been one of the most impressive teams in the NFL considering all of their injuries on both sides of the ball. QB Brock Purdy has been sidelined the last 6 games with a toe injury, but Mac Jones has stepped in and won 4 of 6 starts. The most recent victory came on Sunday night in a 20-10 home triumph over the Atlanta Falcons. RB Christian McCaffrey exploded for over 200 all-purpose yards and finally posted his first 100-yard rushing game this season.

The Texans started the season at 0-3 with 3 losses by 7 points or less. Houston shut out Tennessee for its first victory, followed by a 44-10 rout of Baltimore to improve to 2-3. The Texans couldn’t reach the .500 mark on Monday, as they fell behind early at Seattle in a 27-19 defeat to the Seahawks. QB C.J. Stroud has yet to throw for 250 yards in a game, while coming off his worst quarterback rating of the season at 59.0 against Seattle.

The 49ers are 1.5-point underdogs, marking their 4th straight game in the underdog role. San Francisco is 2-1 straight-up and against the spread when receiving points, including as an 8.5-point ‘dog in the exciting 26-23 overtime victory against the Rams in Week 5. Kyle Shanahan’s team has gone 3-1 on the road this season, which is a stark contrast from the 4-game away skid to close out 2024.

Houston has played a front-loaded road schedule out of the gate with 4 of 6 games away from the Lone Star State. The Texans are 1-1 at home, with the lone loss coming to the Buccaneers in the final minute in Week 2. Houston ranks 5th in the NFL in passing yards allowed per game, while limiting Seattle QB Sam Darnold to 213 yards, his 2nd-lowest output of the season.

The 49ers will be a huge public underdog this week, but the Texans are worth a strong look here looking to bounce back at home.

49ers vs Texans prediction: Houston Texans -1.5 (-110) available at time of publishing. Playable to -2.5.

If you’re looking for a new sportsbook for the football season, we recommend checking out Fanatics Sportsbook. New users can get $250 in FanCash INSTANTLY when they make their first $50 wager! Join Fanatics Sportsbook, where you can bet on our 49ers vs Texans predictions.

Kevin Rogers
Game Totals Pick
Under 41.5(-110)

San Francisco was riding a 3-0 over streak prior to an under in Sunday’s 20-10 home victory over Atlanta. The 49ers allowed 23 points or more in each of those 3 games before limiting the Falcons to 1 touchdown and 1 field goal. QB Mac Jones has thrown only 3 touchdown passes in the last 4 games after posting 3 touchdowns in the Week 2 win at New Orleans.

Houston began the season with 4 consecutive unders before cashing the over in each of the last 2 games against Baltimore and Seattle. The Texans had totals of 41 in both those contests, as Houston blasted Baltimore, 41-10, followed by the 27-19 defeat to the Seahawks. Monday’s game against the Seahawks had an opportunity to stay under the total, but the Texans scored a touchdown with 2 minutes to go to barely go over number.

Houston has allowed an average of 179 passing yards per game, ranking 5th in the NFL. The Texans have not given up more than 245 passing yards in a game this season, which actually came in the Week 1 loss to Matthew Stafford and the Rams. Jones has topped the 340-yard passing mark in each of the last 2 road games against the Rams, who rank 13th in passing yards allowed per game and Buccaneers — who are 18th in that category.

Let’s look at the under here, which is the 2nd-lowest total that San Francisco has seen this season.

49ers vs Texans pick: Under 41.5 (-110) available at time of publishing. Playable to 40.5.

You can bet on our 49ers vs Texans pick with BetMGM, where right now new users can activate your new BetMGM account ⚡ and receive $150 in bonus bets INSTANTLY if your first $10+ wager is a winner!

Kevin Rogers
Photo of Kevin Rogers

Kevin Rogers

Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.
Read more about Kevin Rogers
Pickswise
*
By signing up you agree to our terms and privacy policy