San Francisco 49ers vs Houston Texans Prediction, Odds and Picks for Sunday, 10/26/25

San Francisco (5-2) has been one of the most impressive teams in the NFL considering all of their injuries on both sides of the ball. QB Brock Purdy has been sidelined the last 6 games with a toe injury, but Mac Jones has stepped in and won 4 of 6 starts. The most recent victory came on Sunday night in a 20-10 home triumph over the Atlanta Falcons. RB Christian McCaffrey exploded for over 200 all-purpose yards and finally posted his first 100-yard rushing game this season.

The Texans started the season at 0-3 with 3 losses by 7 points or less. Houston shut out Tennessee for its first victory, followed by a 44-10 rout of Baltimore to improve to 2-3. The Texans couldn’t reach the .500 mark on Monday, as they fell behind early at Seattle in a 27-19 defeat to the Seahawks. QB C.J. Stroud has yet to throw for 250 yards in a game, while coming off his worst quarterback rating of the season at 59.0 against Seattle.

The 49ers are 1.5-point underdogs, marking their 4th straight game in the underdog role. San Francisco is 2-1 straight-up and against the spread when receiving points, including as an 8.5-point ‘dog in the exciting 26-23 overtime victory against the Rams in Week 5. Kyle Shanahan’s team has gone 3-1 on the road this season, which is a stark contrast from the 4-game away skid to close out 2024.

Houston has played a front-loaded road schedule out of the gate with 4 of 6 games away from the Lone Star State. The Texans are 1-1 at home, with the lone loss coming to the Buccaneers in the final minute in Week 2. Houston ranks 5th in the NFL in passing yards allowed per game, while limiting Seattle QB Sam Darnold to 213 yards, his 2nd-lowest output of the season.

The 49ers will be a huge public underdog this week, but the Texans are worth a strong look here looking to bounce back at home.

49ers vs Texans prediction: Houston Texans -1.5 (-110) available at time of publishing. Playable to -2.5.

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