HomeNFLNFL PredictionsSan Francisco 49ers vs Houston Texans Prediction, Odds and Picks

San Francisco 49ers vs Houston Texans Prediction, Odds and Picks for Sunday, 10/26/25

Updated: 5:00 AM ET Oct 27, 2025

NRG StadiumFOX

5-2

49ers

1:00 PM ETSun Oct 26

2-4

Texans

Kevin Rogers

Updated: 5:00 AM ET October 27, 2025

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Kevin covers the NFL for Pickswise from sunny south Florida. He has been handicapping the NFL professionally since 2007, as well the NBA, MLB, NHL, college football, and college basketball. He looks forward to a profitable season at Pickswise.

@RogersPicks

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