San Francisco 49ers vs New York Giants Prediction, Odds and Picks for Sunday, 11/02/25

It shouldn’t matter whether it’s Purdy or Jones under center for San Francisco. The offense does not inspire a whole lot of confidence with either guy running the show. McCaffrey is obviously great, but even though he has stayed healthy this season the running game has been pretty much nonexistent. The Stanford product is more of a receiver for this team. In fact, he is averaging just 3.5 yards per carry. As such, it may not matter that the Giants are terrible against the pass; the fact that they are decent against the pass (6.7 yards per attempt allowed) bodes well for their chances of containing the 49ers. That is part of the reason why my 49ers vs Giants pick is under 48.5.

Skattebo’s absence should not hurt significantly, but it also doesn’t help my any means. It’s also an emotional letdown — especially for Dart. I don’t care how promising the Ole Miss product looks as a rookie; when you are missing your RB1 and WR1 (Malik Nabers is out for the year with a torn ACL), it’s a problem. San Francisco’s defense ranks #11 against the pass and #13 in yards per rushing attempt allowed, so it’s a unit that does not have any huge holes even though it has been dealing with all kinds of injuries. That’s a testament to the acumen of defensive coordinator Robert Saleh. I think all signs point to a relatively low-scoring affair on Sunday.

49ers vs Giants prediction: Under 48.5 (-105) available at time of publishing. Playable to 47.

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