San Francisco 49ers

San Francisco 49ers vs New York Giants Prediction, Odds and Picks for Sunday, 11/02/25

MetLife StadiumCBS
49ers
5-3
49ers
Sun Nov 2
Giants
2-6
Giants
New York Giants
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49ers vs Giants Pickswise Expert Predictions

Point Spread Pick
NY Giants +2.5(-105)

The New York Giants will be hoping to end a 2-game losing streak when they host the San Francisco 49ers in Week 9 of the NFL season on Sunday afternoon. New York really isn’t playing that poorly, however. Head coach Brian Daboll’s squad beat the Eagles in Week 6, was dominating in Denver for 3 quarters in Week 7 and a loss at Philadelphia is obviously nothing to be ashamed about. A home date with an unspectacular San Francisco squad could be just what the doctor ordered to get back on track, so my 49ers vs Giants pick is on the home side to cover.

Cam Skattebo suffered a nasty dislocated ankle in Week 8, but the Giants also have Tyrone Tracy Jr. and Devin Singletary in the backfield. Aside from Skattebo being a sparkplug and emotional leader, that really isn’t any downgrade. As long as Jaxson Dart is under center, New York’s offense can produce. As for the 49ers’ offense, their quarterback situation is once again uncertain. Brock Purdy is questionable with the toe injury that has kept him on the sidelines since Week 1; if he can’t go, it will be Mac Jones once again getting the nod. The Niners have not played well since a 3-0 start. Their only win in regulation since Week 3 has come against an Atlanta team that is in terrible form. San Francisco has dropped 2 of its last 3 games and 3 of its last 5.

49ers vs Giants prediction: New York Giants +2.5 (-105) available at time of publishing. Playable at that number.

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Ricky Dimon
Game Totals PickBest Bet
Under 48.5(-105)

It shouldn’t matter whether it’s Purdy or Jones under center for San Francisco. The offense does not inspire a whole lot of confidence with either guy running the show. McCaffrey is obviously great, but even though he has stayed healthy this season the running game has been pretty much nonexistent. The Stanford product is more of a receiver for this team. In fact, he is averaging just 3.5 yards per carry. As such, it may not matter that the Giants are terrible against the pass; the fact that they are decent against the pass (6.7 yards per attempt allowed) bodes well for their chances of containing the 49ers. That is part of the reason why my 49ers vs Giants pick is under 48.5.

Skattebo’s absence should not hurt significantly, but it also doesn’t help my any means. It’s also an emotional letdown — especially for Dart. I don’t care how promising the Ole Miss product looks as a rookie; when you are missing your RB1 and WR1 (Malik Nabers is out for the year with a torn ACL), it’s a problem. San Francisco’s defense ranks #11 against the pass and #13 in yards per rushing attempt allowed, so it’s a unit that does not have any huge holes even though it has been dealing with all kinds of injuries. That’s a testament to the acumen of defensive coordinator Robert Saleh. I think all signs point to a relatively low-scoring affair on Sunday.

49ers vs Giants prediction: Under 48.5 (-105) available at time of publishing. Playable to 47.

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Ricky Dimon
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Ricky Dimon

Since graduating from Davidson (The College That Stephen Curry Built), I have been writing about sports -- just about any and all you can think of! -- and coaching tennis in Atlanta, GA. Beyond the four major sports, I am an avid tennis fan and cover the ATP Tour on a daily basis. If I'm not busy writing, you can generally find me on a tennis court or traveling the world wherever a sporting event takes me. For Ricky Dimon media enquiries, please email contact@pickswise.com.
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