Tampa Bay Buccaneers vs Seattle Seahawks Prediction, Odds and Picks for Sunday, 10/05/25

A pair of 3-1 clubs hook up in the most intriguing game of the late afternoon slate in Seattle as the Seahawks host the Buccaneers. Tampa Bay won its first 2 road games of the season at Atlanta and Houston, as the Bucs seek victories in their first 3 away contests since 2010. The Bucs are coming off their first loss of the season, falling behind early in a 31-25 defeat to the Eagles. After blowing out Philadelphia at home in each of the past 2 matchups, Tampa Bay trailed 24-3 in the 2nd quarter before cutting the deficit to eight in the 4th quarter. The Bucs held the defending champions to 200 yards of offense, but a pair of turnovers and allowing a blocked punt for a touchdown did Tampa Bay in.

Now, Todd Bowles’ team heads across the country to face Seattle, which is seeking a 4th straight victory after losing the season opener to San Francisco. The Seahawks built a 20-6 lead at Arizona last Thursday night before Arizona rallied to tie the game at 20-20. Jason Myers booted the game-winning field goal for Seattle in the final seconds to give the Seahawks their 8th straight road victory. Playing at Lumen Field in front of the vaunted “12th Man” seemed to be a losing proposition for opponents visiting the Pacific Northwest. That has swung recently, as the Seahawks are 2-7 in their last 9 home games, but one of those victories came 2 weeks ago in a 44-13 rout of the winless Saints. QB Sam Darnold has been impressive in his first season in Seattle, completing 70% of his passes and posting 9.1 yards per attempt, which is tied for 1st in the NFL with Baltimore’s Lamar Jackson.

The Bucs’ RB Bucky Irving is listed as questionable with an ankle injury. If he can’t suit up, Tampa Bay will turn to either Rachaad White or Sean Tucker in the backfield. White has posted 108 rushing yards this season, although he has been held to 17 or fewer yards in 3 of 4 games. Tampa Bay is riding an impressive 10-3 road record since the midway point of the 2023 season. In spite of the Bucs missing WR Mike Evans and potentially Irving, I still believe they have an opportunity here to grab the road victory as an underdog, but believe the safer play will be to take the field goal as extra insurance.

Buccaneers vs Seahawks prediction: Bucs +3.5 (-115) available at time of publishing. Playable to 3.

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