Tennessee Titans vs Arizona Cardinals Prediction, Odds and Picks for Sunday, 10/05/25

Heading into Week 5 of the 2025 NFL season, only three teams have not picked up a win. Both the Jets and Saints return home at 0-4, while the Titans try to get their first victory on the road with a trip to Arizona on Sunday. Tennessee has not scored a touchdown in 2 road losses at Denver and Houston. In last week’s 26-0 shutout defeat to the Texans, the Titans trailed 6-0 headed to the 4th quarter before Houston outscored Tennessee 20-0 in the final 15 minutes. Tennessee’s offense mustered 155 yards, while top NFL draft pick Cam Ward has busted 175 passing yards once in four games.

Arizona jumped out to a 2-0 start with victories over New Orleans and Carolina, who are a combined 1-7. The 2 losses for the Cardinals came on the final play of the game to a pair of division rivals, San Francisco and Seattle. The Cardinals are the only team in the NFC West with multiple division losses, but can still jump above .500 by beating the Titans. Arizona fell in a 20-6 hole last Thursday night against Seattle before rallying with a pair of TDs in the final six minutes to tie the game at 20-20. Following a poor kickoff, the Seahawks were able to drive into field goal range and kick the game-winner, condemning the Cardinals to their 5th division loss in the last 6 tries.

Since the start of the 2024 season, the Titans have stumbled to a disastrous 3-19 ATS record, but all 3 covers came on the road.  Tennessee is 1 of 2 teams in the NFL averaging less than 210.5 yards a game. The only team worse is the Bengals, who are compiling 205.3 yards a game. The Cardinals put together a 4-1 record against AFC foes last season, including a pair of double-digit victories at home against the Jets and Patriots. I’m expecting them to bounce back from last week’s disappointment and to smoothly dismantle the Titans following extended prep time.

Titans vs Cardinals prediction: Cardinals -7.5 (-110) available at time of publishing. Playable to 8.

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