Washington Commanders vs Kansas City Chiefs Prediction, Odds and MNF Picks for Today, 10/27/25

The Washington Commanders, who are suffering through a few key injuries, are really going through a tough time right now. Against the Cowboys, things took a turn for the worst when star quarterback Jayden Daniels went down with a hamstring injury. Considering that Daniels already missed time this season and the franchise can’t afford to lose the former LSU quarterback long-term, trusted medical professionals project Daniels will sit at least 2-3 weeks. This couldn’t have come at a worse time for the Commanders, who will start Marcus Mariota in Week 8, since they have a road spot against one of (if not the) best teams in the NFL on Monday night. The Chiefs started off 2025 in rocky fashion, but they are quickly becoming the same program that’s made 3 straight Super Bowls. In some ways, they look even better than those teams.

Week after week, important Chiefs’ players have returned from injury or suspension, and each week it’s meant better results from Mahomes and his teammates. In Week 7 it was Rashee Rice who returned, further aiding a Kansas City roster that’s already reaching its apex less than halfway through the season. In one of the most disparate box scores you’ll ever see, the Chiefs out-gained the Raiders 434-95 in total yards and, get ready for it, 30-3 in first downs. Of course the Raiders are a complete dumpster-fire and it was hardly a surprise to see a dominant Chiefs’ win, but it was akin to a Super Bowl outfit against a college team. We just don’t see it very often in the modern NFL.

The Commanders are far better than the Raiders overall, but in their current predicament we’re not sure if it’s enough to cover this line. In 2 starts, Mariota has been a decent back-up for Daniels (363 passing yards, 3 touchdowns, 1 interception). But last week, against a motivated Dallas-defense, he instantly proved why he’s a huge step down from #5, throwing a hellacious interception and unable to move the offense in Daniels’ absence. Aside from left tackle Josh Simmons, who’s dealing with something mysterious that’s keeping him off the field (Andy Reid has yet to expand on what’s happening), the Chiefs are completely healthy, at home, and look as potent and buttoned up as they ever have. The choice is clear.

Commanders vs Chiefs prediction: Kansas City Chiefs -10 (-110) available at time of publishing. Playable to 10.5.

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