NFL Picks

NFL picks for every game of the 2025-26 season. Our NFL expert picks are informed by key betting trends, statistical analysis and years of NFL betting experience. +25.7 units of profit, from 177 winning picks so far this season is the proof.

Our NFL picks this week include against the spread picks for every game in week 12, highlighted by Bills vs Texans on Thursday night football, Buccaneers vs Rams on SNF and Monday Night football, featuring Panthers vs 49ers.

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8:15 PM ET

Tomorrow

Amazon Prime Video

Bills

Texans

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Point Spread Pick

HOU Texans +5.5(-110)

Reasoning

Thursday Night Football gets NFL Week 12 started as the Buffalo Bills head to NRG Stadium to take on the Houston Texans.

Week 11 was a microcosm of who the Bills and Texans are, and in many ways, they couldn’t be more different. Buffalo is nothing without their quarterback. In a full display of the quintessential Josh Allen experience, Allen threw some preposterous interceptions, lending Tampa easy scoring situations on multiple occasions. On the other hand, Allen completely dominated the Bucs’ defense, gaining 6 total touchdowns along with 317 passing yards and 40 rushing yards. Most of the contest was a back-and-forth affair, as markets expected, and the Bills’ defense wasn’t exactly buttoned up. Tampa piled up 21 first downs and 32 points on 367 total yards, including an impressive 9-16 conversion rate on 3rd downs. Once again, the Bills’ front-seven proved it’s not championship caliber right now, allowing 202 rushing yards to a Bucs ground game that’s not highly ranked in that area (22nd).

The Texans won in Week 11 in the exact opposite way, as they do most weeks. Without CJ Stroud, Houston was in a tough position facing a division rival off their bye week, but they did a good job maintaining their composure. In yet another low-scoring game, the Texans managed to eventually gain 315 yards, more than enough to take out a Titans offense that looked pedestrian throughout the contest. The fact that they allowed Tennessee to hang around so long wasn’t a good look, but it was evident that the Texans were clearly the better program. Their defense, which remains the #1 unit in the NFL, was once again their anchor. Surviving the scare, Houston faces a much bigger test at home on just a few days of rest.

While these 2 teams aren’t the same as last season, the Texans won in a low-scoring 23-20 battle the last time they faced off. If they want to have a chance against Allen and the Bills, they’ll need to control the game in the same manner. More than any of the other 3 units in this battle, the Texans’ defense has been the most consistent. We’ll count on them to keep it closer than the market expects.

Bills vs Texans prediction: Texans +5.5 (-110) available at time of publishing. Playable to 4.5.

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Game Totals Pick

Under 43.5(-110)

Reasoning

Since the Bills and Texans are built so differently, predicting a total becomes that much more challenging. Houston sits in 3rd in the AFC South despite owning the NFL’s best defense, a group that allows just 16.3 points (1st) and 258.1 yards (1st) per game. It looks like they’ll still be without CJ Stroud on Thursday Night Football, who remains in concussion protocol, but with or without CJ Stroud, their offense just hasn’t been very good this season. They average just 22 points (21st) and gain just 329.6 yards per game (19th). Davis Mills has done a good job in Stroud’s absence (726 yards, 60% completion rate, 3 touchdowns, 1 interception), but the Bills are better against the pass than they are against the run. Buffalo is top-5 in sack rate and holds opposing QBs to just 169.7 passing yards per game (2nd).

We think Houston will score here and there, but this total will be decided when the Bills are on offense. Josh Allen is incomparable and impossible to accurately predict. He’s also prone to making mistakes against great defenses. Last season a very similarly constructed Texans’ resistance completely stymied the future Hall of Famer, limiting the Bills’ leader to just 9-30 for only 131 yards. When Buffalo has success on the ground, they generally have a big offensive day. They’re first in rush yards per game (147.6), but the Texans are also top-3 in that category defensively, permitting just 3.9 yards per rush. This total has to carry some weight because the game features Josh Allen, but it’s a tick too high considering the home team’s style.

Bills vs Texans pick: Under 43.5 (-110) available at time of publishing. Playable to 43.

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Anytime Touchdown Scorer Pick

J. Allen (BUF) to score a TD(-105)

Reasoning

Over the last couple of seasons, I’ve often targeted Josh Allen to find the end zone with his legs, and those tickets have cashed repeatedly. As we have seen over the years, the Bills often turn to their superstar quarterback to dig them out of a hole when the chips are down, and he typically uses his legs to do so. Now in his 3rd year as the offensive coordinator, Joe Brady’s reliance on Allen’s legs in pivotal spots has been consistent all season long, and I expect that to continue on TNF in a game where the Bills need to win in order to keep pace with the Patriots in the race for the AFC East division crown.

Allen racked up a whopping 9 touchdowns on the ground in between Week 10 and Week 16 a season ago as the Bills made a push for seeding in the AFC playoff picture. While I don’t quite expect that level of insane production this time around, it’s notable that Allen finished with 6 total touchdowns a week ago, including 3 on the ground. The Wyoming product has found the end zone with his legs in 3 of the Bills’ last 4 contests, and it wouldn’t surprise me at all if Allen gets multiple opportunities in the red zone in this one. Given the fact that his rushing workload around the goal line has ticked up in recent weeks, this prop still feels a bit mispriced at the current number, so let’s take advantage and back Allen to score a touchdown once again on Thursday Night Football.

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Caleb Wilfinger

Same Game Parlay

Alternate Point Spread

HOU Texans +3.5

Player Rushing Yards

W. Marks (HOU) - Over 63.5 rush yds

Anytime Touchdown Scorer

J. Allen (BUF) to score a TD

Reasoning

Houston Texans +3.5 alternate spread over Buffalo Bills (+122)

I simply can’t bet against the Texans’ defense. Playing at home helps, as well. All things considered, I think Houston can make this game low scoring to the extent that it should be able to stay within a field goal – if not even win it outright. The Texans are #1 in the league by a country mile in total defense, holding opponents to 258.1 yards per game. They are also #1 in scoring (16.3 points per game allowed), #3 in passing (171.0 yards), #3 in rushing (87.1 yards) and #5 in turnovers forced (16).

Davis Mills will likely be back under center for Houston with CJ Stroud in concussion protocol, but Mills is a capable backup who has a lot of experience. Meanwhile, Buffalo has lost 2 of their last 3 road games, including by 10 points against Atlanta and by 17 points against Miami. And those 2 teams aren’t even good!

Woody Marks over 63.5 rushing yards (-114)

There is no denying that the Texans have struggled on the ground this season, but even they can find success against this Bills outfit. Buffalo is atrocious against the run, giving up the 2nd-most rushing yards per contest at 153.0. Its 5.4 yards per carry allowed are also the 2nd-most league-wide. Marks may not be anything special, but the rookie out of USC is capable of taking advantage. He has churned out 62 yards or more in 3 of the last 7 outings and in 2 of the last 4. Marks should get plenty of attempts as well, given that it is in Houston’s best interest to keep the ball on the ground, move the clock and relegate Allen to the sideline for as long as possible.

Josh Allen anytime touchdown scorer (-115)

I have no qualms about throwing this leg into our Bills vs Texans SGP despite picking Houston to keep it within a field goal. Head coach DeMeco Ryans’ team needs to contain everyone else in order to be competitive. We – the Texans included – can accept Allen finding the end zone as a given. He has scored a ridiculous 7 touchdowns in the last 4 contests, including 3 in this past Sunday’s victory over Tampa Bay. Obviously, Houston’s defense is amazing, but that could actually work in Allen’s favor when it pertains to this particular bet. He will probably have to do a lot of improvising when his first reads are taken away. Count on him doing a lot of stuff by himself – that includes taking one in for a score.

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1:00 PM ET

Sun Nov 23

CBS

Steelers

Bears

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Point Spread PickBest Bet

CHI Bears -2.5(-115)

Reasoning

The Chicago Bears have won 7 of their last 8 games heading into a home date with the Pittsburgh Steelers on Sunday afternoon. I’m hopping on the bandwagon, so my Bears vs Steelers pick is on the home side to win and cover. It is fair to say that the Bears have found their stride under first-year head coach Ben Johnson and second-year quarterback Caleb Williams. With Williams playing mistake-free football, D’Andre Swift balancing the offense by running the ball effectively and Johnson’s play-calling working its magic just as it did when he was offensive coordinator in Detroit, Chicago’s offense is humming. It is #4 overall (373.8 yards per game) and #8 in scoring (25.8 points per game). Williams has thrown only 4 interceptions to go along with his 16 total touchdowns (13 passing, 3 rushing).

Pittsburgh’s QB situation is far worse. On Sunday the visitors will either be playing with a banged-up Aaron Rodgers or a backup in Mason Rudolph. Rodgers is questionable after sustaining minor fracture in his left wrist during last week’s victory over Cincinnati. It was announced on Tuesday that that injury will not require surgery. Whatever the case, neither Rodgers nor Rudolph inspires much confidence. On the other side of the ball, the Steelers’ defense is overrated. Everyone just assumes it is good since TJ Watt is on the field, but that is hardly the reality. Head coach Mike Tomlin’s team is #28 league wide in total defense and dead last against the pass. Its 33 sacks are good for third most in the NFL, but keep in mind that Williams is a mobile quarterback who can avoid pressure for the most part. At home against an unspectacular opponent, I feel great about Chicago maintaining momentum.

Pittsburgh Steelers vs Chicago Bears prediction: Bears -2.5 (-115) available at time of publishing. Playable to -3.

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Game Totals Pick

Over 44.5(-120)

Reasoning

Both teams should be able to move the ball relatively well in this matchup, regardless of what Rodgers’ status ends up being. Obviously Rodgers’ presence would help Pittsburgh, but it’s not like the 41-year-old is irreplaceable at this point of his career. Rudolph is a capable backup who has plenty of experience, plus Chicago’s defense is nothing special. As such, my Steelers vs Bears pick is Over 44.5. The Bears are #23 in the NFL against the pass and have recorded only 21 sacks, so either Rodgers or Rudolph should be in decent shame for at least a decent amount of success on Sunday. Running back Jaylen Warren has averaged at least 4.7 yards per carry in 5 of his last 6 games, having previously gained no more than 3.4 in his first 3 contests. The Oklahoma State product has averaged 5.2 and 6.0 in the past 2 outings.

As for the Bears’ offense, it is a well-oiled machine. Swift is often injured, but right now he is armed with a clean bill of health. The former Georgia standout has racked up 634 rushing yards and 210 receiving yards through 9 appearances so far this year. Williams has not been picked off since Week 8 — and during his 3-game stretch of mistake-free football, Chicago is scoring 30.0 ppg. Expect a relatively high-scoring affair when these 2 teams tangle this weekend.

Pittsburgh Steelers vs Chicago Bears prediction: Over 44.5 (-120) available at time of publishing. Playable at that number.

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4:05 PM ET

Sun Nov 23

CBS

Jaguars

Cardinals

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Point Spread PickBest Bet

JAX Jaguars -2.5(-112)

Reasoning

The Arizona Cardinals have lost 7 of their last 8 games heading into a home date with the Jacksonville Jaguars during Week 12 of the NFL season on Sunday afternoon. Once 2-0, the Cardinals are now 3-7 and aren’t even looking competitive. They have dropped 2 consecutive contests by at least 19 points. Arizona is only a slight underdog against Jacksonville because it is playing at home, but does that really matter? Probably not! After all, the Cards have lost 4 home games in a row — including to the lowly Titans. Tennessee (1-9) has not won a single other game this entire year. This is simply a fantastic time to fade head coach Jonathan Gannon’s squad, so my Jaguars vs Cardinals pick is on the visitors to win and cover.

Jacksonville, on the other hand, is playing solid football. Its worst loss since Week 2 is against the Texans — but even a 1-possession setback on the road in Houston is nothing to be ashamed about. The Jaguars are coming off a 35-6 beatdown of the Chargers this past weekend. It is true that the Bolts’ offensive line is in absolute shambles, but that is still an extremely impressive result any way you slice it. The Jags churned out 192 rushing yards, which bodes well for their chances of finding success against a mediocre Cardinals defense. This is a tale of 2 teams going in opposite directions, and I think that trend will continue on Sunday.

Jacksonville Jaguars vs Arizona Cardinals prediction: Jaguars -2.5 (-112) available at time of publishing. Playable to -3.

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Game Totals Pick

Over 47.5(-105)

Reasoning

The Cardinals have given up more than 40 points in back-to-back outings; the Jaguars are averaging more than 30 over their last 3 contests. It’s safe to say that none of that is encouraging for Arizona’s defense heading into Sunday’s matchup. As such, my Jaguars vs Cardinals pick is Over 47.5. Jacksonville running back Travis Etienne has scored 3 touchdowns on the ground over the past 2 games and he is now facing an Arizona defense that has surrendered 11 rushing TDs in 2025 (tied for the ninth most in the league). Quarterback Trevor Lawrence has thrown too many interceptions this season (8), but half of those came in the first 3 weeks.

If there is any good news for the Cards, it’s that Jacoby Brissett is filling in decently enough for Kyler Murray — who is out with an ankle injury and not expected to start again in 2025. Brissett just torched San Francisco for 452 yards on 47-of-57 passing to go along with 2 touchdowns. His TD-to-INT ratio through 5 starts this season is 10-to-3, including 8-to-2 over the past 4 outings. Brissett now faces a Jacksonville defense that is #26 in the NFL against the pass and has allowed the fourth-most touchdowns through the air.

Jacksonville Jaguars vs Arizona Cardinals prediction: Over 47.5 (-105) available at time of publishing. Playable at that number.

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4:25 PM ET

Sun Nov 23

FOX

Falcons

Saints

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Point Spread Pick

NO Saints -1.5(-110)

Reasoning

It will be a showdown in the NFC South when the New Orleans Saints host the Atlanta Falcons on Sunday afternoon. It would have been hard to believe if before the season someone told you that the Saints — even at home — would be favored over the Falcons in Week 12. But that is, in fact, the case. It obviously has nothing to do with the Saints, who have been predictably bad. The Falcons, though, may be the most disappointing team in the entire league. Their 5-game losing streak has them at 3-7 overall and now both quarterback Michael Penix Jr. and wide receiver Drake London are sidelined. Penix will miss at least the next 4 games due to a knee injury; London is out 1 week at minimum with a knee issue of his own. Kirk Cousins under center and throwing to a group of pass-catches that doesn’t include London is a recipe for disaster.

The Saints own an even worse record than their division rivals, but they are a respectable 2-4 in their last 6 contests. Signs of improvement — however slim — are on display. They disposed of Carolina 17-7 in Week 11 — the same Carolina team that just swept the regular-season series against Atlanta. Now the Saints are coming off bye, which is a huge advantage heading into this matchup. New Orleans has won each of its last 3 home games against Atlanta. Expect that streak to continue this weekend.

Atlanta Falcons vs New Orleans Saints prediction: Saints -1.5 (-110) available at time of publishing. Playable at that number.

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Game Totals Pick

Under 39.5(-110)

Reasoning

You can’t feel good about either offense in this matchup. The Falcons’ offensive attack went into the 2025 campaign with high expectations, but the receiving corps does not have much outside of London, Penix has underwhelmed at quarterback and the offensive line is in shambles. Tackles Kaleb McGary and Storm Norton are on injured reserve, while guard Matthew Bergeron is questionable for Sunday because of an ankle injury. Speaking of London and Penix, neither will play on Sunday. That is part of the reason why my Falcons vs Saints pick is Under 39.5.

Rookie QB Tyler Shough has taken over from Spencer Rattler in New Orleans — early returns are not overly encouraging. In 4 appearances (3 starts), the 26-year-old out of Louisville has completed 61.4 percent of his passes with 3 touchdowns and 2 interceptions. Shough has logged meaningful minutes in 3 games; in those 3 the Saints have scored 3, 10 and 17 points. Prior to the bye they played a boring 17-7 game against the Panthers. This one may not be quite that bad, but offense will almost certainly be minimal.

Atlanta Falcons vs New Orleans Saints prediction: Under 39.5 (-110) available at time of publishing. Playable at that number.

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Ricky Dimon

8:15 PM ET

Mon Nov 24

ESPN

Panthers

49ers

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Point Spread PickBest Bet

SF 49ers -6.5(-115)

Reasoning

Markets and NFL media heads are high on the Panthers after they did something highly unusual: win a big game on the road with Bryce Young under center. Even more unusual was Young’s form. The former Alabama star made Panthers history last Sunday, throwing for a franchise game-high 448 yards and 3 touchdowns in a winning effort at Atlanta. Down 21-10 at halftime, at one point Young had to exit to Carolina’s locker room to address a new ankle injury. Immediately it felt like the same old story; an ailing group under new coach Dave Canales — who can’t quite get it right. The Panthers’ offense caught fire, along with their defense permitting just 92 yards and 6 second-half points. History will see Week 11 as an impressive comeback win for Canales’ group, a roster that’s proving it’s not built the same as previous iterations.

Unfortunately, we’re here to spoil the party. While the Panthers win was impressive, we must consider their opponent. After starting the season looking like a formidable NFC contender, the Falcons loss on Sunday was their fifth in a row. Even worse, Michael Penix Jr., their second-year starter who took over for Kirk Cousins last season, left with what’s likely a season-ending knee injury. Atlanta’s defense has also been floundering for over a month. This Sunday Carolina will face a much bigger road challenge. The 49ers are coming off an inspiring victory on Sunday, one that left their fans hopeful that this season may have a higher ceiling than once thought. San Francisco leveraged 3 Arizona turnovers, but with Brock Purdy back the offense was smooth and explosive — turning 5 red-zone possessions into 4 touchdowns. The Niners clobbered their rivals 41-22 on their enemy’s home field, and — perhaps most importantly — Purdy looked fantastic (19-for-26, 200 yards, 7.7 yards per pass, 3 touchdowns). It was the kind of win that catalyzes future success.

The Panthers deserve a ton of credit for their turnaround this season, but the 49ers still have championship fabric throughout their roster — including a coach and quarterback pairing who are as effective as any in the NFL. The Niners’ offense is also healthier than it’s been all season, with Jauan Jennings, Ricky Pearsall and George Kittle all ready to roll for Week 12. I like the home team to pull away.

Panthers vs 49ers best bet: 49ers -6.5 (-115) available at time of publishing. Playable to 7.

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Game Totals Pick

Over 48.5(-115)

Reasoning

We should start by stating the obvious: no NFL team has more overs this season than the San Francisco 49ers. They are 7-3-1 to the over through 11 weeks. Of course, part of that is because of their litany of defensive injuries. Entering Week 12, they have 6 defensive players on injured reserve — including their 2 best players, Nick Bosa and Fred Warner. Because of those injuries they have consistently allowed points (22.9), but their offense is a big part of it, too. Whether it was Brock Purdy or Mac Jones, their offense continues to be production. After all, it’s run by Kyle Shanahan — widely regarded as one of the NFL’s best playcallers. The Niners have gained 349.4 yards per game, a top-10 mark, and now that their playmakers are healthy their average points are bound to rise (currently 23.7 per game, 15th).

The Panthers’ offense is unlikely to perform as well as they did this past Sunday (30 points, 486 yards), but they can still do some damage on Sunday. The Niners’ defense simply hasn’t been very good regardless of who has been on the field. According to advanced EPA metrics, they are 31st in defensive success rate and 27th in defensive success rate. They have also allowed 114 points in their past 4 games. I don’t necessarily expect Bryce Young to have a repeat performance in the Bay Area this Sunday, but the Niners’ secondary is a bottom-5 program in EPA per pass. Plus, Young’s Week 11 showing should only produce more confidence. They can surely get into the 20s.

Panthers vs 49ers prediction: Over 48.5 (-115) available at time of publishing. Playable to 49.5.

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Why Trust our NFL Picks

Through week 11 of the 2025 season our team of NFL handicappers have made against the spread and totals picks for every game, with 177 wins (and 3 pushes) our record speaks for itself. Across these markets our expert NFL picks have scored +25.7 units of profit so far this season.

NFL Picks	Wins	Push	Losses	Profit (betting units)
Sides (Moneyline & ATS)	90	2	71	+20
Totals (Over/Under)	87	1	75	+5.7
All Picks	177	3	146	+25.7

At Pickswise, every NFL pick is backed by years of betting experience, advanced data analysis, and a proven track record of success. Our team of handicappers studies line movement, injury reports, historical trends, and matchup stats to deliver informed recommendations — not guesses. We publish our results openly, update our predictions as new information emerges, and never hide behind vague analysis. Whether you’re looking for expert spreads, totals, props, or parlays, our mission is simple: give you honest, well-researched picks that stand up over time.

Free NFL Picks Explained

We firmly believe expert NFL picks should be free, so you’ll find our NFL picks today, and every day of the season, right here. We publish our free NFL picks for every game, at least a few days in advance of gameday, so you know who the experts are backing without missing out on the early value in the betting markets.

There’s almost an infinite way to bet on the NFL, from NFL picks against the spread, moneyline, over/under, NFL Parlays, and NFL Prop Bets, there is a bet type for every kind of football fan, so we provide NFL picks for every bet type. Some bettors like to specialize in a single particular type of NFL pick, while others like to have a diverse range and bet on anything they feel is a value pick.

Here at Pickswise, we have something for everyone. Our team of handicappers have a wealth of experience in making NFL picks across all these betting markets, leaving no stone unturned ahead of every game and every pick of the 2025 NFL season. If you’re looking for more information on NFL bet types, You can find our expert breakdown of each below.

NFL Picks Against the Spread

The most popular way to bet on the NFL is against the spread (ATS). With these wagers, you are not picking a simple winner or loser of a game. Instead, ATS betting is placing your money that Team A wins by a certain amount of points or that Team B will keep the game closer than oddsmakers expect, in other words, not lose by that same amount of points.

For Example

Philadelphia Eagles -7 – Philadelphia must win by 8 or more points to cover the spread.
Chicago Bears +7 – Chicago must win, or lose by 6 or fewer points to cover the spread.
Tie Scenario – If the game ended 27-20 to Philadelphia, the spread would be a tie, or a push and stakes would be returned.

NFL spread betting trends 2025

The team that covers the spread wins the game outright around 80% of the time.
Road teams going into games as the favorite have covered the spread at 64% so far this season
Teams coming off a blowout loss (20+ points) tend to rebound against the spread, 57% of the time.

Free NFL Over / Under Picks

Another exciting way to still get in on the NFL action is with totals wagers. In these bets you don’t take a side, but whether the two teams will combine to score over or under the total number of points that the oddsmakers have set. Already since sports betting has been legalized we’ve seen many occasions where a hail mary, missed FG or XP has cost over or unders bettors, so be prepared to be in for the long haul with your totals bets. We preview every game of the NFL season, providing insight into the game as a whole alongside expert NFL picks so you can make informed NFL totals bets.

NFL over / under betting trends

Overall, unders have proven the value pick in recent seasons, as defenses have caught up with scoring trending down since 2021
Unders bets have the edge in divisional games, landing 57% of the time. This trend gets stronger late in the season (week 13 onwards), especially in cold weather conditions.
Unders bets have landed on 58% of primetime games, as public betting tends to have a bias for the overs in these games.

Money Line NFL Picks

Ask any seasoned NFL bettor and they’ll tell you that ATS betting is exciting, but can also be frustrating. It is important to keep in mind that NFL teams only need to win by one, of course, they’d love to win by more, but they’ll change their schemes late on to secure a win, not to ensure they cover the spread. Your research could have given you the right side, but if they win by 6 instead of 7 your -6.5 bet is a loss. Therefore a lot of bettors like to keep it simple and take our expert NFL Money Line picks and bet on the NFL straight up.

NFL Moneyline betting trends

Through the first 4 weeks of the 2025 season 6+ point favourites have been strong straight up, with a 16-2-1 record
Short underdogs (+1 to +3 on the spread) win outright 43% of the time, offering better value on the moneyline than the spread
Underdogs in lower scoring road games (less than 42 total points) win outright 39% of the time, but often at better prices than this record suggests.

2025-26 NFL Schedule

This will be the 106th season in league history and is set to kick off with the NFL Kick-Off game on Thursday, September 4, hosted by the defending Super Bowl Champions Philadelphia Eagles, who take on the Dallas Cowboys. The regular season will come to a conclusion on January 4, 2026 with the NFL Playoffs scheduled to begin the following weekend on the 10th, 11th & 12th of January 2026. Super Bowl LX is scheduled for February 8, 2026, at Levi’s Stadium in San Francisco, California, the home of the 49ers.

NFL Playoff Picks

You can find our NFL picks for the 2026 Playoffs, right here, for free. Wildcard Weekend is scheduled to start January 10, upon the conclusion of week 18 our experts start to make their picks and predictions for the first round of the playoffs and after each round is concluded we prepare for the coming weekend, all the way up to the Super Bowl.

NFL Playoff Picks
NFL Wildcard Weekend Picks
NFL Divisional Round Picks
NFL Conference Championship Picks

NFL Expert Picks

Our NFL Football picks will be for every game throughout the regular season, with primetime games and the top matchups each week getting additional expert coverage which will extend to every playoff game. These NFL Football picks will come alongside analysis and the latest stats and trends to consider when betting. You can also find our NFL Best Bets for the top plays of the week and a confidence rating for our expert handicapper.

Looking for alternative football picks? then head to our College Football Picks page, where you’ll find the same level of expertise from the Pickswise handicapping team for all the headline games in the 2025 NCAA football season.

More Than Just NFL Football Picks

We also specialize in every major North American sport including the MLB, NBA, NHL, College Football, and College Basketball. Check out our site every day for some of the best bets in every major athletic contest and make sure to follow us on social media as well.

Andrew Wilsher, Managing Editor of Pickswise

Statistical Approach to NFL Picks

It’s our goal to provide you with the best NFL picks in the market. Our expert handicappers are all specially selected and assessed prior to joining the team to ensure their analysis. experience and results are among the best in the industry. Each capper will put hours of research into each pick and many have built statistical models to find their moneyline, spread and over/under picks so you don’t have to. Check out all of our cappers’ free NFL picks here every week of the season.

Andrew Wilsher, Pickswise Managing Editor

NFL Picks FAQs

How Do You Pick Against The Spread In The NFL?

To bet against the spread in the NFL you are either betting the favorite to win by x number of points or the underdog to win, or lose by fewer than x points. For example the Chiefs -7 points or the Panthers +7 points.

The number of points is set by sportsbooks and is often referred to as the line

What Is The Best Website For NFL Picks Against The Spread?

Pickswise is the best website to get free NFL picks against the spread. Our handicappers provide free insight, analysis, and data to back up which way they’re siding against the spread for every NFL game. So far this NFL season our experts have secured 86 winning NFL picks for a profit of 26 units

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Pickswise is the best place to get free expert NFL picks. We have the best cappers and NFL picks on the market and you can get all of our NFL picks for free! every week.

Each pick is meticulously researched by an experienced NFL handicapper, using our own data, custom-built models, and analytical methods. Our profit this season is 26 units and rising, so don’t miss out on the best NFL picks this week.